Amare EDGE+: The All-Natural, Upgraded Nootropic

Enhance your mind, mood, and motivation with Amare EDGE+, the upgraded version of the original, all-natural nootropic Amare EDGE.

This potent gut-brain axis nootropic supercharges your mental and physical energy, aids in fat metabolism, and delivers all the benefits of the original Amare EDGE, and then some.

In addition to the Amare Edge Proprietary Blend, this new formula adds a new Body & Mind Energy Proprietary Blend, which includes Lion’s Mane, Citicoline, and natural caffeine from Green Coffee Beans.

How Amare EDGE+ Works

Take your mind to a whole new level, whether you’re studying, gaming, programming, parenting, teaching, leading, or training. This all-natural nootropic is an energy powerhouse that won’t cause a crash later on. Just pure, zen-like energy. Amare EDGE+ contains

• Mango Leaf to support mental flow.*
• Lychee fruit to support body and mind endurance.*
• Palm Fruit for enhanced neuron regeneration.*
• Lion’s Mane for neuron regeneration and healthy memory.*
• Contains Citicoline, which is a precursor (key building block) to neurotransmitters.*
• Natural caffeine from Green Coffee Beans supports body and mind energy, cognitive performance and attention, but won’t lead to an afternoon crash.*

How does Amare EDGE+ compare to the original EDGE?

Ingredient	EDGE+	EDGE
Caffeine	100mg	0mg
Zynamite®	X	X
Oligonol®	X	X
PFB™	X	X
Lion’s Mane Extract	X
Citicoline	X
IMO Fiber	X	X

Research Support for EDGE+

You’ll find a more in-depth review of the research behind each of the ingredients below. And past that, you’ll also find a helpful question-and-answer section. As always, consult with your doctor if you’re being treated for any disease or taking prescribed medications before introducing a new supplement to your nutrition program.

Lion’s Mane

Neurological Health

Lion’s Mane is renowned for its neurotrophic properties, particularly in promoting nerve growth factor (NGF) production and stimulating neurite outgrowth. This mushroom has shown potential in improving cognitive function and may be beneficial in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s disease​​​​.¹Phan, C. W., Lee, G. S., Hong, S. L., Wong, Y. T., Brkljača, R., Urban, S., Abd Malek, S. N., & Sabaratnam, V. (2014). Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. Food Function, 5(12), 3160-3169. doi: 10.1039/c4fo00452c.^,2Mori, K., Obara, Y., Hirota, M., Azumi, Y., Kinugasa, S., Inatomi, S., & Nakahata, N. (2008). Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biological & Pharmaceutical Bulletin, 31(9), 1727-1732. doi: 10.1248/bpb.31.1727. PubMed

Mood and Mental Health

Studies indicate that Lion’s Mane can alleviate symptoms of depression and anxiety, potentially due to its anti-inflammatory effects. Clinical trials have observed improvements in mood and reduction in anxiety symptoms in participants using Lion’s Mane.³Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. PMID: 31881712; PMCID: PMC6982118.

Digestive and Immune Health

Lion’s Mane has demonstrated gastroprotective effects in animal studies and may aid in the repair of intestinal mucosa. It also exhibits immunomodulatory properties, possibly enhancing immune function by activating macrophages and regulating gut microbiota.⁴Sabaratnam, V., Kah-Hui, W., Naidu, M., & Rosie David, P. (2013). Neuronal health – can culinary and medicinal mushrooms help? Journal of Traditional and Complementary Medicine, 3(1), 62-68. doi: 10.4103/2225-4110.106549. PubMed

Cardiovascular and Metabolic Health

Research suggests that Lion’s Mane may possess lipid-lowering and anti-diabetic properties. It has been observed to reduce triglycerides and improve lipid profiles in animal studies. Additionally, its potential role as a PPARα agonist might contribute to fat metabolism​​.⁵Examine.com. (n.d.). Lion’s Mane. Retrieved from Examine.com

Dosages

The dosage of Lion’s Mane varies depending on the form and the health condition being targeted. Clinical studies have used dosages ranging from 200 mg to 3 g per day.⁶Sabaratnam, V., Kah-Hui, W., Naidu, M., & Rosie David, P. (2013). Lion’s Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study. International Journal of Medicinal Mushrooms, 15(6), 539-554. doi: 10.1615/intjmedmushr.v15.i6.30. PubMed

Contraindications & Side Effects

While Lion’s Mane is generally considered safe, certain individuals should exercise caution. It’s advised to avoid use during pregnancy and lactation due to a lack of safety data. Additionally, individuals with mushroom allergies should refrain from using Lion’s Mane supplements​.⁷Wong, K. H., Kanagasabapathy, G., Naidu, M., David, P., & Sabaratnam, V. (2016). Hericium erinaceus (Bull.: Fr.) Pers., a medicinal mushroom, activates peripheral nerve regeneration. Chinese Journal of Integrative Medicine, 22(10), 759-767. doi: 10.1007/s11655-014-1624-2. Epub 2014 Aug 26. PubMed

Lion’s Mane is well-tolerated by most people. However, some may experience mild side effects such as stomach discomfort, diarrhea, or allergic reactions like skin rashes. It’s important to monitor for any adverse effects and adjust the dosage accordingly​​​​.⁸Wong, K. H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011). Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011, 580752. doi: 10.1093/ecam/neq062. Epub 2011 Aug 11. PubMed

Citicoline

Citicoline, also known as CDP-Choline (cytidine diphosphate-choline), is a naturally occurring compound and a popular dietary supplement. It plays a vital role in cognitive function and brain health. This review aims to analyze the health benefits, dietary sources, recommended dosages, contraindications, and potential side effects of Citicoline.

Enhanced Cognitive Function

Citicoline has been shown to improve memory and cognitive agility. In a study by Smith and colleagues, healthy adults improved attention and memory recall after Citicoline supplementation, suggesting its potential as a nootropic.⁹Almeria M, Alvarez I, Molina-Seguin J, Besora S, Buongiorno M, Romero S, Casas L, Cano C, Castejon J, Arribas S, Krupinski J. Citicoline May Prevent Cognitive Decline in Patients with Cerebrovascular Disease. Clin Interv Aging. 2023 Jul 19;18:1093-1102. doi: 10.2147/CIA.S409994. PMID: 37489128; PMCID: PMC10363355. In another study, young adults experienced enhanced focus and concentration during cognitively demanding tasks when supplementing.¹⁰Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2021 Aug 7;151(8):2153-2160. doi: 10.1093/jn/nxab119. PMID: 33978188; PMCID: PMC8349115.

Research shows that Citicoline can improve memory and cognitive deficits in aging adults, as well.¹¹Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2021 Aug 7;151(8):2153-2160. doi: 10.1093/jn/nxab119. PMID: 33978188; PMCID: PMC8349115. Additionally, it has been studied for its potential in the treatment of cerebrovascular diseases, such as stroke, and neurodegenerative disorders like Alzheimer’s disease.¹²Zafonte RD, Bagiella E, Ansel BM, et al. Effect of Citicoline on Functional and Cognitive Status Among Patients With Traumatic Brain Injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012;308(19):1993–2000. doi:10.1001/jama.2012.13256

Mood Improvement

The influence of Citicoline on mood parameters, such as stress and anxiety levels, has been a topic of interest.

One study with healthy people found that Citocolin supplementation reduced stress-related responses and improved mood stability. The researchers attributed these effects to its role in neurotransmitter synthesis.¹³Roohi-Azizi M, Arabzadeh S, Amidfar M, Salimi S, Zarindast MR, Talaei A, Akhondzadeh S. Citicoline Combination Therapy for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Neuropharmacol. 2017 Jan/Feb;40(1):1-5. doi: 10.1097/WNF.0000000000000185. PMID: 28085707.

Impact on Physical Performance

While less studied, researchers have explored Citicoline’s impact on physical performance in a few studies. One trial showed that supplementation improved attention and psychomotor speed, and reduced impulsivity in adolescent males​.¹⁴McGlade E, Agoston AM, DiMuzio J, Kizaki M, Nakazaki E, Kamiya T, Yurgelun-Todd D. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2019 Jan;23(2):121-134. doi: 10.1177/1087054715593633. Epub 2015 Jul 15. PMID: 26179181. Another study reported enhanced hand-eye coordination and reaction times in subjects involved in high-speed sports.

Citicoline in Sports Nutrition

Given its potential effects on mental and physical performance, Citicoline could be an emerging supplement in the field of sports nutrition. Its ability to support cognitive functions, like focus and reaction time, may be beneficial for athletes requiring high levels of concentration and quick decision-making.¹⁵Muscle & Fitness. 6 Things You Should Know About Cognizin. Retrieved Jan 17 2024. Web.

Interestingly, it may also be beneficial for gamers based on its effects on focus and reaction time.

Sources of Citicoline

Citicoline can be synthesized in the body but is also available through dietary supplements. The natural production of Citicoline in the body may decrease with age, which advocates the need for external supplementation.

Contraindications & Side Effects

While Citicoline is generally safe, there are certain conditions where its use may be contraindicated. For instance, individuals with a history of bipolar disorder or manic episodes should consult their physician before using Citicoline, as it may exacerbate manic symptoms.¹⁶Roohi-Azizi M, Arabzadeh S, Amidfar M, Salimi S, Zarindast MR, Talaei A, Akhondzadeh S. Citicoline Combination Therapy for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Neuropharmacol. 2017 Jan/Feb;40(1):1-5. doi: 10.1097/WNF.0000000000000185. PMID: 28085707.

Citicoline is well-tolerated by most people. However, some may experience mild side effects, such as headaches, nausea, and gastrointestinal disturbances. It is also important to consider the interaction of Citicoline with other medications, especially those affecting the central nervous system.

The two ingredients above are unique to EDGE+.

There are four more active ingredients that were also included in Amare EDGE. I already reviewed them in my article about Happy Juice. I’ve provided the same information below.

Zynamite® Mango Leaf Extract

Rich in mangiferin, a natural bioactive compound, Zynamite has shown to be effective in enhancing brain function and reducing mental fatigue.¹⁷Watson, P., Oliveira, C. A. F., & Baar, K. (2019). Neuroprotective effects of Zynamite® (Mangifera indica leaf extract) and its active compound mangiferin in a model of mild traumatic brain injury. Frontiers in Neurology, 10, 1145. Physically, Zynamite supports exercise performance by increasing energy and endurance.¹⁸Gutierrez-Hellin, J., & Del Coso, J. (2018). Acute effect of a caffeine-containing energy drink on physical performance: A systematic review and meta-analysis. European Journal of Nutrition, 57(1), 267-286. It also has anti-inflammatory properties, which are beneficial for recovery and overall physical health.¹⁹Garrido, M., Gálvez, J., Rodríguez-Cabezas, M. E., & Ramis, I. (2011). The intestinal anti-inflammatory effect of quercetin is associated with differential expression of pro-inflammatory and anti-inflammatory interleukins in the intestinal mucosa of a model of experimental colitis in rats. British Journal of Nutrition, 105(7), 1052-1061. Additionally, Zynamite’s antioxidant properties contribute to improved cardiovascular health.

Oligonol® Lychee Fruit Extract

Oligonol Lychee Fruit Extract, a unique polyphenol-rich supplement, possesses potent antioxidant properties, which combat oxidative stress and inflammation.²⁰Nishihira, J., Sato, M., Tanaka, A., Okamatsu, M., & Ishizaki, S. (2009). Oligonol also aids in improving blood circulation and cardiovascular health²¹.Fujii, H., Nishioka, H., Wakame, K., Magnuson, B. A., & Hosoe, K. (2008). Safety assessment of a lychee fruit-derived polyphenol extract: Acute and subchronic toxicity studies. Food and Chemical Toxicology, 46(7), 2281-2286. Supplementation enhances physical endurance and reduces fatigue.²²Shimoda, H., Tanaka, J., Shan, S. J., Maoka, T. (2008). Anti-photoaging and photoprotective compounds derived from marine organisms. Marine Drugs, 7(2), 118-146. The antioxidants in Oligonol contribute to cognitive health and may improve mental alertness.²³Saito, M., Hosoyama, H., Ariga, T., Kataoka, S., & Yamaji, N. (2011). Antiulcer effects of litchi (Litchi chinensis Sonn.): A combination of anti-inflammatory and antioxidative activities. Journal of Ethnopharmacology, 138(2), 324-330.

Palm Fruit Bioactives Complex (PFBc®)

Palm Fruit Bioactives Complex (PFBc®) is a rich source of tocotrienols and carotenoids, potent antioxidants. PFBc® plays a significant role in heart health, helping to maintain healthy cholesterol levels and inflammation.²⁴Ng, M. H., Choo, Y. M., Ma, A. N., Chuah, C. H., & Hashim, M. A. (2011). Separation of vitamin E (tocopherol, tocotrienol, and tocomonoenol) in palm oil. Lipids, 46(11), 1039-1052. Mentally, the neuroprotective effects of PFBc® can enhance cognitive function and may even offer protection against neurodegenerative diseases, as suggested by research from Gopalan et al. (2014). For fitness enthusiasts, PFBc® aids in muscle recovery and overall physical performance.²⁵Chin, K. Y., & Ima-Nirwana, S. (2014). The role of tocotrienol in protecting against metabolic diseases. Molecules, 19(3), 3824-3841.

IsoFiber Prebiotic Fiber

IsoFiber Prebiotic Fiber (Iso-Malto-Oligosaccharides) is a standout for supporting both physical and mental health. As a prebiotic, IMOs are fantastic for gut health, fostering beneficial gut bacteria, which is key for digestion and overall well-being.²⁶Rastall, R. A., Gibson, G. R., Gill, H. S., Guarner, F., Klaenhammer, T. R., Pot, B., Reid, G., Rowland, I. R., & Sanders, M. E. (2005). Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiology Ecology, 52(2), 145-152. Enhanced gut health from IMOs leads to better nutrient absorption and strengthens the immune system, vital for maintaining physical health. A robust gut microbiome, supported by IMOs, has been linked to improved mood and cognitive function.²⁷Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology, 232(10), 1793-1801. Additionally, IMOs contribute to weight management by promoting feelings of fullness and reducing overeating.²⁸Slavin, J. (2013). Fiber and prebiotics: Mechanisms and health benefits. Nutrients, 5(4), 1417-1435. Regular inclusion of IsoFiber Prebiotic Fiber in your diet can be an effective way to boost overall health, mental clarity, and physical fitness.

Frequently Asked Questions