Need Better Sleep? Try Corn Leaf, also Known as Maizinol®

About a month ago, I wrote a huge article about melatonin. I emphasized the importance of this hormone for not only sleep, but also for numerous other health benefits. But, as essential as melatonin is for health, supplementing with melatonin isn’t always the best solution for supporting sleep.

A large percentage of people complain of melatonin hangovers when they supplement with it. They might fall asleep faster, but they often wake up feeling groggy and more tired than they would have without it. It’s not unlike the side effects of some sleep medications, which improve the quantity of sleep, but do little to improve the quality of it.

Fortunately, there’s a potent, natural compound that enhances sleep quality as well as quantity, and does so without side effects. Unfortunately, few people know about it. It’s called Maizinol, a patented compound derived from the leaf of Zea mays, which you might know better as corn. You read that right. An extract from the leaf of non-GMO corn could be the solution to finally getting better sleep.

In a world where sleep disorders and stress are becoming increasingly common, finding a natural, effective, and safe solution is more important than ever. Maizinol promises just that. Its efficacy is not just a claim; it’s backed by solid scientific evidence and research.

In the following sections, we’ll delve into the science behind Maizinol, its benefits, the clinical evidence supporting its efficacy, and how it compares to other sleep aids.


A unique, research-supported supplement for improving sleep quantity and quality. Clinical evidence shows it leads to:

  • 50% improvement in sleep efficiency*
  • 40% improvement in sleep quality*
  • 33% reduction in time to fall asleep*
  • 30% fewer nighttime wakeups*

Clinical Evidence Supporting Maizinol

Unlike many generic sleep-related supplements, Maizinol is a patented ingredient backed by legit clinical research. The following are the three biggest effects of supplementing according to that research.

1. Improvement in Sleep Quality

When it comes to evaluating the effectiveness of any sleep aid, the proof lies in the quality of sleep it can induce. Maizinol stands out in this regard, as evidenced by several clinical studies. These studies have consistently demonstrated that Maizinol, a natural extract derived from corn leaves, can significantly improve sleep quality.

One of the key measures used to assess sleep quality in these studies is the Pittsburgh Sleep Quality Index (PSQI). The PSQI is a standardized and widely recognized tool used by sleep researchers to gauge various aspects of sleep quality, including duration, disturbances, latency, and overall sleep efficiency.

In human clinical trials, Maizinol has shown notable improvements in sleep quality as measured by the PSQI. Participants who used Maizinol experienced an enhancement in their sleep patterns, particularly in the deep sleep stage, which is crucial for restorative sleep.1Unigen. (n.d.). Maizinol: Improving sleep quality in human clinical studies. Retrieved from Unigen website

In a specific study, researchers found that supplementation with Maizinol led to an increase in the deep sleep stage of sleep by almost 30 minutes. This increase is significant compared to a mere four-minute increase observed in the placebo group.2Brownell, L., Vice President of Clinical Research and Regulatory Compliance at Unigen. (n.d.). Maizinol™: Increasing deep sleep stage. Retrieved from Nutraceuticals World Deep sleep, also known as slow-wave sleep, is vital for physical recovery, immune function, and overall health. By extending the duration of this critical sleep stage, Maizinol helps ensure that the body gets the restorative rest it needs.

Moreover, the improvement in sleep quality was not just limited to the quantity of deep sleep. Participants also reported feeling more refreshed upon waking, indicating an overall enhancement in the quality of their sleep. This is a crucial factor, as feeling well-rested is just as important as the actual time spent in various stages of sleep.

These findings are promising and underscore the potential of Maizinol as a natural alternative to synthetic sleep aids. Unlike many conventional sleep medications that can have adverse effects and lead to dependency, Maizinol offers a safer and more holistic approach to improving sleep quality.

2. Reduction in Stress and Less Disrupted Sleep

In addition to enhancing sleep quality, Maizinol has also shown promising results in reducing stress indicators, particularly cortisol levels. Cortisol, commonly known as the “stress hormone,” plays a crucial role in various bodily functions, including metabolism, immune response, and the body’s response to stress. However, elevated cortisol levels, especially at night, can disrupt sleep patterns and overall well-being.

Clinical studies have provided valuable insights into the effects of Maizinol on cortisol levels. In a notable study involving participants who supplemented with Maizinol, researchers observed a statistically significant and dose-correlated reduction in salivary cortisol levels. The reduction was up to 36%, a substantial decrease that points towards the effectiveness of Maizinol in managing stress.3UP165, A Standardized Corn Leaf Extract. (n.d.). Reduction in salivary cortisol levels with Maizinol® supplementation. Retrieved from NCBI.

The study’s findings are particularly important because they highlight Maizinol’s role in helping maintain healthy cortisol levels. By doing so, Maizinol reduces the likelihood of premature waking and other sleep disturbances often caused by elevated cortisol levels. This aspect of Maizinol is crucial for individuals who struggle with stress-induced sleep disruptions.

Moreover, the ability to maintain healthy cortisol levels not only improves sleep quality but also contributes to overall well-being. Cortisol is intricately linked to various health aspects, including mood, immunity, and metabolic processes. Therefore, the regulation of cortisol levels through natural means such as Maizinol supplementation can have far-reaching benefits beyond just improved sleep.

3. Dosage and Efficacy

Clearly, Maizinol works. But what is the best dosage?

In a double-blind, placebo-controlled clinical trial, the effects of Maizinol were assessed at two different dosages: 250 mg and 500 mg per day. The study included a diverse group of participants, aged between 19 and 73, who consumed either the supplement or a placebo approximately 60 minutes before bedtime, daily for a period of four weeks.4UP165, A Standardized Corn Leaf Extract. (n.d.). Dosage and efficacy of Maizinol® in sleep quality and well-being. Retrieved from NCBI

The findings of this study were significant. Participants who received the 250 mg dosage of Maizinol reported noticeable improvements in their sleep quality. However, those who took the higher dosage of 500 mg experienced even more pronounced benefits.5Talbott SM, Talbott JA, Brownell L, Yimam M. UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State. J Med Food. 2023 Jan;26(1):59-67. doi: 10.1089/jmf.2021.0197. Epub 2022 Sep 30. PMID: 36179066; PMCID: PMC9889011.

  1. Enhanced Sleep Quality: Both dosages led to improvements in sleep quality, but the 500 mg dosage yielded a greater enhancement as measured by the Pittsburgh Sleep Quality Index (PSQI). This indicates that while even a lower dose of Maizinol can be effective, a higher dose may provide more substantial improvements in sleep quality.
  2. Increased Deep Sleep Duration: Consistent with the overall improvement in sleep quality, participants taking the higher dosage of Maizinol reported a significant increase in the duration of deep sleep, which is critical for physical and mental rejuvenation.
  3. Reduced Stress Indicators: Alongside better sleep, the higher dosage also correlated with a more pronounced reduction in stress indicators, particularly cortisol levels. This further supports the role of Maizinol in managing stress-related sleep issues.

These results are particularly encouraging as they suggest that Maizinol can be tailored to individual needs. While a standard dose may suffice for some, others may find greater benefit from a higher dosage. Importantly, these benefits were achieved without any reported adverse effects, underscoring the safety of Maizinol as a natural sleep aid.

Maizinol® vs. Other Sleep Aids

When trying to get better sleep, you’re often faced with a plethora of options, ranging from natural remedies to synthetic pharmaceuticals. Understanding how Maizinol stacks up against other sleep aids is crucial for making an informed choice. This section compares Maizinol with other common sleep aids, focusing on its natural origin, consumer compliance, and ease of use.

Natural vs. Synthetic Sleep Aids

Maizinol stands out primarily due to its natural, plant-based origin. Derived from the leaves of non-GMO Zea mays (corn), it offers a more holistic approach to improving sleep. This contrasts with many synthetic sleep aids, which are often formulated with chemically manufactured compounds. While synthetic options can be effective, they sometimes come with a risk of side effects or dependency, concerns that are increasingly leading people to seek natural alternatives.

The natural composition of Maizinol is not only appealing but also aligns with a growing preference for wellness products that are perceived as safe and non-invasive. The fact that Maizinol is derived from a commonly consumed and well-regarded food source adds to its appeal, positioning it as a gentle yet effective option for those cautious about introducing synthetic substances into their bodies.

Compliance and Ease of Use

Another significant advantage of Maizinol is its once-a-day dosing, which increases consumer compliance. Consistency is key in any supplement regimen, and the simplicity of a single daily dose makes it easier to incorporate Maizinol into your daily routines. This contrasts with some other sleep aids that may require more complex dosing schedules or are recommended only for short-term use due to potential side effects or dependency risks.

Read also: More Evidence Sleep Debt Makes You Fatter.

Safety and Efficacy

The safety of Maizinol has been rigorously evaluated in various preclinical studies. These studies are essential to establish the supplement’s safety profile before it is tested in human clinical trials. Preclinical tests typically involve in vitro (test tube) and in vivo (animal) studies to assess the potential toxicity, side effects, and safe dosage ranges of the substance. For Maizinol, these tests have consistently shown no adverse effects, indicating a high level of safety for human use.

The absence of negative outcomes in these tests is a strong indicator of Maizinol’s suitability as a sleep aid. Given that it is derived from the leaves of Zea mays, a commonly consumed and well-regarded food source, the likelihood of adverse reactions is further minimized. This aspect is particularly crucial for individuals who are cautious about introducing new supplements into their regimen, especially those with sensitivities or allergies.

Preclinical Efficacy

In addition to safety, preclinical studies also provide insights into the efficacy of Maizinol. These tests help in understanding how the active compounds in Maizinol interact with biological systems, laying the groundwork for the observed effects in human clinical trials. For instance, the ability of Maizinol’s natural compounds to bind to melatonin receptors, as shown in preclinical models, is a critical factor in its effectiveness as a sleep aid.

Understanding these mechanisms is important not only for validating the benefits of Maizinol but also for advancing our broader knowledge of natural sleep aids. It demonstrates how plant-based compounds can be both gentle and effective, challenging the notion that stronger, synthetic options are always better.

Practical Summary

Maizinol stands out as a natural, effective solution for those seeking better sleep and reduced stress. Its ability to improve sleep quality, as evidenced by increases in deep sleep duration and enhancements measured by the Pittsburgh Sleep Quality Index, is remarkable. Remember, deep sleep is crucial for your physical and mental rejuvenation, and Maizinol helps you achieve more of this restorative stage each night.

But Maizinol’s benefits extend beyond just sleep. Its impact on reducing stress and mood indicators, particularly cortisol levels, makes it a comprehensive solution. Lower cortisol levels are associated with better sleep quality and a reduced likelihood of sleep disturbances, contributing to a more balanced and relaxed state of being.

Now, it’s your turn to take a step towards better sleep and reduced stress. Consider integrating Maizinol into your wellness routine. Whether you’re struggling with sleep disturbances, managing stress, or simply looking for a natural way to enhance your sleep quality, Maizinol offers a promising solution.

You’ll find it as one of the key ingredients in Amare’s Sleep+.


A unique, research-supported supplement for improving sleep quantity and quality. Clinical evidence shows it leads to:

  • 50% improvement in sleep efficiency*
  • 40% improvement in sleep quality*
  • 33% reduction in time to fall asleep*
  • 30% fewer nighttime wakeups*

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.