From cardiac patient to competitive athlete, depressed to diabetic, growing up to growing old…you need magnesium. And you need more than you’re probably getting.

At least two-thirds of adults get less than the paltry RDA, which is 400-420 mg for men and 310-320 mg for women, making magnesium the second most-common micronutrient deficiency, next to vitamin D.

If you hope to meet your magnesium needs through food alone, good luck with that. Most people need to supplement to get enough.

Before you stop into a retail store and buy the lowest-priced magnesium you can find, read through this article so you know what to look for.

The last thing I’d want for you is to buy the cheap stuff and end up with diarrhea in the middle of your squat workout, or when you’re in the window seat on an airplane.

I’ll cover why it’s so important, why we don’t get enough, how to choose the right magnesium supplement, and what I use myself. You’ll understand why magnesium is part of my Foundational Five, the five foundational supplements for (almost) every nutrition program.

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Why Is Magnesium So Important?

At any given time, you store about 25 grams of magnesium in your body, a little less than an ounce. About half is stored in your bones, half in organs and tissues and about one percent in your blood.

It plays a role in more than 300 enzymatic reactions, impacting almost every system in the body.

Cardiovascular Health

Inflammation is a major factor in heart disease.

Magnesium supports normal inflammation levels through multiple pathways. In fact, low-grade inflammation from insufficient magnesium could contribute to a whole host of health problems.

Studies show those with low magnesium are more likely to have elevated C-reactive protein (hs-CRP), the main marker of systemic inflammation. And correcting low magnesium levels can lower CRP levels.

Elevated blood sugar and blood pressure also increase cardiovascular risk, both of which can be improved by meeting your magnesium needs.

Energy Production

Magnesium plays a role in energy production, assisting with the extraction of energy from food. It supports the proper utilization of amino acids, fat, or carbohydrates. It also aids in the creation of adenosine triphosphate (ATP), the energy currency of every cell in your body.

Nerve impulse conduction requires magnesium. No nerve impulse, no ability to move a muscle, control your heart rhythm, or have a functioning brain.

Magnesium is required for the utilization of other micronutrients, such as B-complex vitamins, vitamin C, and vitamin E.

Read also: What You Need to Know About Digestive Enzymes.

Blood Sugar, Insulin Resistance, and Diabetes

Magnesium supports normal blood sugar levels and is needed for proper insulin metabolism. Those with insulin resistance, diabetes, and/or metabolic syndrome are often deficient.

Elevated blood sugar is toxic to the body, so insulin is secreted when blood sugar levels rise. Over time, the body becomes numb to the effects of insulin (insulin resistant), and blood sugar levels don’t come down.

Taking magnesium won’t eliminate the chance of becoming insulin resistant or diabetic. You still have to stop eating a lousy diet. But it can help you better manage your blood sugar, which is a step in the right direction.

Muscle Function and Bone Health

Magnesium is necessary for muscle contraction. If levels fall too low, nerve conduction and muscle contraction can be affected, which could lower muscle strength and power.

Opposite contraction, magnesium is also necessary for relaxation. Cramps can be an obvious sign of low magnesium, but so is restless leg syndrome.

While calcium is important for bone health, osteoporosis risk jumps when magnesium levels decline. Magnesium, calcium, vitamin D and vitamin K are all important for maintenance of bone density with age.

Depression and Anxiety

In all of my reading and research, I was most fascinated by low magnesium’s connection to depression.

Some believe the neural damage brought on by low magnesium diets can lead to feelings of depression.

Magnesium insufficiency lowers serotonin, which can also contribute to depression. This explains why many people experience a calming effect from magnesium.

Researchers found that taking 125-300 mg with each meal and at bedtime reversed symptoms of depression in those who have low-magnesium related depression.

It’s not just depression though. Low magnesium, or even an excess intake of calcium compared to magnesium, can lead to feelings of agitation, anxiety, irritability, confusion, sleeplessness, and headaches. Anxiety during PMS also seems to be connected to low levels as well.

Likely connected to the brain and serotonin effects of magnesium, low levels are also tied to migraine headaches and attention deficit hyperactivity disorder.

Read also: Irritable Male Syndrome, Andropause, and Reclaiming Your Manhood.

Learning and Memory

Since low magnesium has such a strong connection to depression, I’m not surprised it also has connection to the progression of neurodegenerative diseases.

Magnesium controls synaptic plasticity, which affects learning and memory.

Developing Alzheimer’s, Lewy Body disease, and other forms of dementia are real fears for aging adults. At this point, there is nothing known to stop or reverse cognitive decline, but some evidence suggests sufficient magnesium intake can help slow the progression.

…all elements of the limbic–hypothalamus–pituitary–adrenocortical axis are sensitive to the action of Mg. Magnesium has also been demonstrated to suppress hippocampal kindling, attenuate the release of, and affect adrenocortical sensitivity to, adrenocorticotrophic hormone (ACTH), and may influence the access of corticosteroids to the brain at the level of the blood brain barrier via its action on p-glycoprotein.”
– Boyle NB et al. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review

Magnesium and Exercise

Animal studies show that magnesium deficiency increases free radical production during exercise.

Physical stress also increases the use of magnesium, making competitive athletes and fitness enthusiasts more at risk of insufficiency if they don’t supplement.

Magnesium is necessary for optimal muscle contraction, making it essential for athletes. It also plays an important role in the immune, endocrine (hormones), and cardiovascular systems.

All that said, there doesn’t seem to be a benefit in excessive intake. Once you reach an optimal level, taking more doesn’t create an ergogenic effect.

Read also: Vigor: 5 Simple Habits for Better Men’s Health.

What Causes Low Magnesium Levels?

Insufficient intake, or excessive magnesium excretion contribute to low magnesium levels.

Increased Excretion or Use of Magnesium

Sugar consumption increases the use of magnesium. So does excessive physical or mental stress.

Proton pump inhibitors like Nexium® and Prevacid® and antacids decrease magnesium absorption, while loop and thiazide diuretics increase magnesium excretion.

Fluoride, commonly found in tap water, and excessive zinc (>142 mg/day) can reduce magnesium absorption as well.

Though higher-fiber intakes are generally considered healthy, partially fermentable fibers like hemicellulose, or non-fermentable fibers like cellulose and lignin can interfere with magnesium absorption.

Also, exercise increases excretion, which may increase daily requirements by 10-20%

Insufficient Intake

Unfortunately, it’s difficult to consume sufficient magnesium through the diet.

Food processing strips most of the magnesium found in grains, and fortified foods contain minimal amounts of poorly absorbed forms of magnesium.

Also, even the best multivitamins rarely contain enough magnesium because magnesium chelates take up so much space, you’d need to take 2-4 additional capsules per day.

Lastly, the Recommended Daily Allowance is hardly an ideal amount. It is more of an estimate of how much you need to avoid more obvious deficiency symptoms, and is based on questionable research.

How to Increase Magnesium Levels

You do find magnesium in certain foods, such as (unprocessed) whole grains, dark leafy greens, beans and legumes, and certain types of nuts.

In addition, proteins, medium-chain triglycerides (MCTs), and low or indigestible carbohydrates like resistant starch, oligosaccharides, and inulin, enhance magnesium absorption.

However, even with a good diet, you probably won’t get enough from food alone.

Supplement With Magnesium

Magnesium supplements are available in a variety of forms, which makes it confusing to pick the right one.

I’ll briefly touch on your options, and then share with you what I use.

Organic vs Inorganic Magnesium

When describing minerals, “organic” doesn’t have the same meaning you’re familiar with as it relates to food.

Magnesium isn’t found on its own in supplements. It is bound to another molecule or compound (i.e. magnesium glycinate).

When magnesium is bound to a carbon-containing molecule, it’s considered “organic,” and when the molecule doesn’t contain a carbon atom, it’s considered inorganic.

“Organic” magnesiums are not any safer, so don’t be fooled by a product that boosts “Organic Magnesium Chelate.” All magnesium forms, if you take enough, should raise blood, tissue, and brain levels, but some forms do seem to provide greater advantages for certain tissues than other.

However, some of the organic chelates do have the best absorption. Also, if you take too much of some forms of magnesium, they can cause diarrhea. That’s great if your constipated, but not so great if you’re not, and you suddenly have to go when there’s no place to go.

Read also: Coffee: Is it good for you?.

The Best Magnesium Supplements

The following table outlines the “best” forms of magnesium. However, in my opinion, you probably only need two on a daily basis. Two others can be useful for constipation or for a relaxing bath.

TYPE BENEFITS
Magnesium Carbonate Helpful for those with indigestion or acid reflux
Magnesium Chloride Commonly recommended for supporting detoxification and kidney function
Magnesium Citrate Helpful with constipation as it is a mild laxative
Magnesium Glycinate Best absorbed form of magnesium
Magnesium Malate Can be helpful for those with fatigue as malic acid is involved in ATP production
Magnesium Oxide Most common form in over-the-counter constipation medications
Magnesium Sulfate Also known as Epsom Salt, this magnesium is often added to a bath, but can also be used internally, though it does have a laxative effect like magnesium oxide
Magnesium Threonate Seems to have an advantage over other magnesium forms for promoting brain function

My Magnesium Recommendations

I’d rather take fewer of the best absorbed and highest-quality forms of magnesium, than take a ton of diarrhea-inducing, lower-quality magnesium pills.

The two magnesium supplements I use and most often recommend come from Pure Encapsulations. You can get your hands on them (or other professional-quality brands) by setting up a Wellevate account below.

They are magnesium glycinate and magnesium threonate.

Magnesium Glycinate

Magnesium glycinate is the best-absorbed form of magnesium. Magnesium glycinate raises blood, bone, and tissue levels of magnesium without causing loose stools or digestive upset.

Because the magnesium is bound to glycine, you also get the benefits of glycine along with magnesium. Glycine is an amino acid that supports digestion and healthy joints, as well as calms the mind and supports restful sleep.

I use Pure Encapsulations Magnesium Glycinate or Thorne Magnesium Bisglycinate.

Magnesium Threonate

Low levels of magnesium in the brain contributes to a loss of plasticity, which translates to cognitive decline. However, most forms of magnesium have minimal effect on magnesium levels in the brain.*

Magnesium-L-threonate, developed by scientists at MIT, does increase magnesium levels in the brain.*

Animal research shows it improves learning abilities, working memory, and short and long-term memory. A mouse model of Alzheimer’s disease showed that magnesium threonate supplementation prevented or reversed synapse loss and memory loss.*

In older adults with existing cognitive problems, supplementing with magnesium threonate increased brain levels of magnesium, as expected. They also experienced improvements in executive function, memory, and problem solving abilities.*

I use Pure Encapsulations CogniMag.

Summary

We often dismiss the importance of micronutrients by putting too much attention on carbohydrates, protein, and fat. However, when we fall short of micronutrients like magnesium, we can create some pretty significant health problems.

Magnesium is safe to supplement with and easy to take.

I personally use, and most often recommend Pure Encapsulations Magnesium Glycinate and Magnesium Threonate.

Sign up for a Wellevate account and get 15% off any of the professional-quality products available, along with free shipping when your order is over $49. Go get your magnesium!

Show References

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Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4)971-990.

Natural News. The best and worst forms of magnesium to take as a supplement. https://www.naturalnews.com/046401_magnesium_dietary_supplements_nutrient_absorption.html

Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Mag Res 2006;19(3):180-189

Rayssiguier Y, Gueux E, Nowacki W, et al. High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation. Magnes Res 2006;19:237-43.

Rock E, Astier C, Lab C, et al. Dietary Magnesium deficiency in rats enhances free radical production in skeletal muscle. J Nutr 1995;125:1205-1210.

Schuchardt JP, Hahn A. Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update. Curr Nutr Food Sci 2017;13(4):260-278

Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuoron. 2010;65(2):165-177

Song Y, Manson JE, Buring JE, Liu S. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Diabetes Care 2004;27(1):59-65

Song Y, Sesso HD, Manson JE, et al. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol. 2006;98(12)1616-1621

Spencer H, Norris C, Williams D. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 1994;13:479-84

Wang J, Liu Y, Zhou LJ, et al. Magnesium L-threonate Prevents and Restores Memory Deficits Associated with Neuropathic Pain by Inhibition of TNF-?. Pain Physician 2013;16:E563-E575

Wei Li, Jia Yu, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014;7(65)