Article References

Papers referenced for blog articles. Articles are sorted alphabetically. I use this page for references to reduce the word count on the actual articles, which helps improve the page loading speed.

6 Health Benefits Of The Sauna (And How To Get The Most Out Of It)

Article found here: 6 Health Benefits Of The Sauna (And How To Get The Most Out Of It).

Blum N, Blum A. Beneficial effects of sauna bathing for heart failure patients. Exp Clin Cardiol. 2007;12(1):29-32.

Ernst E, Pecho E, Wirz P, Saradeth T. Regular sauna bathing and the incidence of common colds. Ann Med. 1990;22:225-227.

Ftaiti F, Jemni M, Kacem A, et al. Effect of hyperthermia and physical activity on circulating growth hormone. Appl Physiol Nutr Metab. 2008;33(5):880-887.

Hannuksela ML, Ellahham S. Benefits and Risks of Sauna Bathing. Am J Med. 2001;110:118-126.

Kokura S, Adachi S, Manabe E, et al. Int J Hyperthermia. 2007;23(3):259-265.

Kunutsor SK, Laukkanen T, Laukkanen JA. Sauna bathing reduces the risk of respiratory disease: a long-term prospective cohort study. Eur J Epidemiol. 2017;32:1107-1111

Laitinen LA, Lindqvist A, Heino M. Lungs and ventilation in sauna. Ann Clin Res. 1988;20:244-248.

Laukkanen JA, Laukkanen T. Sauna bathing and systemic inflammation. Eur J Epid. 2018;33:351-353

Laukkanen T, Kunutsor S, Kauhanen J, et al. Sauna bathing is inversely associated with dementia and Alzheimer’s disease in middle-aged Finnish men. Age and Aging. 2017;46;245-249

Laukkanen T, Kunutsor SK, Zaccardi F, et al. Acute effects of sauna bathing on cardiovascular function. J Human Hyperten. 2018;32;129-138 Polycythemia (High Red Blood Cell Count). Online article. Retrieved Aug 14, 2018.

Magalhães FD, Amorim FT, Freitas Passos RL, et al. Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans. Cell Stress Chaperones 2010;15:885–895.

Masuda A, Koga Y, Hattanmaru M, Minagoe S, Tei Ch. The effects of repeated thermal therapy for patients with chronic pain. Psychother Psychosom. 2005;75:288-294.

Naito H, Powers SK, Demirel HA, et al. Heat stress attenuates skeletal muscle atrophy in hindlimb-unweighted rats. J Appl Physiol 88: 359–363, 2000.

Pilch W, Szygula Z, Klimek AT, et al. Changes in the lippid profile of blood serum in women taking sauna baths of various duration. Int J Occup Med Environ Health. 2010;23(2):167-174.

Pilch W, Szygula Z, Palka T, et al. Comparison of physiological reactions and physiological strain in healthy men under heat stress in dry and steam heat saunas. Biol Sport. 2014;31:145-149

Saadat H, Sadeghi R, Motamedi MR, et al. Potential Role of Thermal Therapy as an Adjunct Treatment in Congestive Heart Failure. J Teh Univ Heart Ctr. 2009;3:149-158.

Selsby JT, Dodd SL. Heat treatment reduces oxidative stress and protects muscle mass during immobilization. Am J Physiol Regul Integr Comp Physiol 289: R134–R139, 2005.

Selsby JT, Rother S, Tsuda S, et al. Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. J Appl Physiol. 2007;102:1702-1707.

Sutkowy P, Wo?niak A, Boraczy?ski T, et al. The effect of a single Finnish sauna bath after aerobic exercise on the oxidative status in healthy men. Scand J Clin Lab Invest. 2014;74(2):23-94

7 Body and Mind Benefits of Building Muscle

Article found here: 7 Body and Mind Benefits of Building Muscle.

Bryner RW, Ullrich IH, Sauers J, et al. Effects of Resistance vs. Aerobic Training Combined With an 800 Calorie Liquid Diet on Lean Body Mass and Resting Metabolic Rate. J Am Coll Nutr. 1999;18(1):115-121

Colby SL, Ortman JM. The Baby Boom Cohort in the United States: 2012 to 2060. United Census Bureau Current Population Reports. May 2014.

Giang V. The Surprising And Powerful Links Between Posture and Mood. Fast Company. Jan 30 2015. Retrieved June 24 2018.

Grace Rattue. “Diabetes Population May Rise To 53 Million Within 13 Years In USA.”Medical News Today. MediLexicon, Intl., 18 May. 2012. Web.

Koopman R, van Loon LJC. Aging, exercise, and muscle protein metabolism. J Appl Physiol. 2009;106:2040-2048

Lemmey AB, Marcora SM, Chester K, et al. Effects of a High-Intensity Resistance Training in Patients With Rheumatoid Arthritis: A Randomized Controlled Trial. Arth & Rheu. 2009;61(12):1726-34

National Center for Chronic Disease Prevention and Health Promotion. Diabetes Report Card. CDC. 2012. Retrieved Sept 12, 2014.

Pennings B, Groen B, de Lange A, et al. Amino acid absorption and subsequent muscle protein accre- tion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 2012;302:E992-9.

Solerte SB, Gazzaruso C, Bonacasa R, et al. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol. 2008;101(11A):69E-77E

Witard OC, Jackman SR, Breen L, et al. Myofibrillar muscle protein synthesis rates subsequent to a meal in re- sponse to increasing doses of whey protein at rest and after resistance exercise. Am J Clin Nutr 2014;99:86–95.

Yang Y, Breen L, Burd N, et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr 2012;108:1780–8. 

9 Strength Training Benefits For Health, Fitness, And Anti-Aging

Article found here: 9 Strength Training Benefits For Health, Fitness, And Anti-Aging

Fitzgerald SJ, Blair S. Muscular fitness and all-cause mortality: prospective observations. J Phys Act Health. 2004;1:17-18.

Hagerman F, Walsh S, Staron R, et al. Effects of high-intensity resistance training on untrained older men: strength, cardiovascular, and metabolic responses. J Gerontol A Biol Sci Med Sci. 2000;55:8336-8346.

Ibanez J, Izquierdo M, Arguelles I, et al. Twice weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care. 2005;28:662-667.

Jensen J, Rustad PI, Kolnes AJ, Lai YC. The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise. Front Physiol. 2011;2:112.

Hunger GR, Bryan DR, Wetzstein CJ, et al. Resistance training and intra-abdominal adipose tissue in older men and women. Med Sci Sports Exerc. 2002;34:1025-1028.

Preethi S, Karlamangla AS. Muscle Mass Index as a Predictor of Longevity in Older-Adults. Am J Med. 2014;127(6):547-553.

Strasser B, Schobersberger W. Evidence of resistance training as a treatment therapy in obesity. J Obes. 2011;482564.

Trappe S, Williamson D, Godard M, Gallagher P. Maintenance of whole muscle strength and size following resistance training in older men. Med Sci Sports Exerc. 2001;33:S147.

Treuth MS, Hunger GR, Kekes-Szabo T, et al. Reduction in intra-abdominal adipose tissue after strength training in older women. J Appl Physiol. 1995;78:1425-1431.

Treuth MS, Ryan AS, Bratley RE, et al. Effects of strength training on total and regional body composition in older men. J Appl Physiol. 1994;77:614-620.

Wescott WL. Resistance Training is Medicine Effects of Strength Training on Health. Curr Sport Med Rep. 2012;11(4):209-216.

Westcott WL. Strength training for frail older adults. J Active Aging. 2009;8:52-59.

9 Reasons To Stop Doing Cardio Or Endurance Training

Article found here: 9 Reasons To Stop Doing Cardio Or Endurance Training

Anderson T, Lane AR, Hackney AC. Cortisol and testosterone dynamics following exhaustive endurance exercise. Eur J Appl  Physiol. 2016;116(8):1503-1509.

Bojana P, Popovic D, Djuro A. Exercise Stress: Focus on Catabolic /Anabolic Interplay Between Cortisol, Testosterone, and Sex Hormone Binding Globulin in Professional Athletes. J Med Biochem. 2019;38(1):6-12.

Bosco C, Viru A. Testosterone and cortisol levels in blood of male sprinters, soccer players and cross-country skiers. Biol Sport. 1998;15(1):3-8.

Chung N, Park MY, Kim J, et al. Non-exercise activity thermogenesis (NEAT): a component of total daily energy expenditure. J Exerc Nutrition Biochem. 2018;22(2):23-30.

Crewther BT, Cook C, Cardinale W, et al. Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones. Sports Med. 2011;41(2):103-23.

Hackney AC. Effects of endurance exercise on the reproductive system of men: the /exercise-hypogonadal male condition/. J Endocrinol Invest. 2008;31:932-938.

Hagmar M, Hirschberg AL, Bergland L. Special attention to the weight-control strategies employed by Olympic athletes striving for leanness is required. Clin J Sport Med. 2008;18(1):5-9.

Hamill J, Gruber AH. Is changing footstrike pattern beneficial to runners? J Sport Health Sci. 2017;6(2):146-153.

Healy ML, Ginny J, Pentecost C, et al. Endocrine profiles in 693 elite athletes in the post-competition setting. Clin Endocrinol (Oxf). 2014;81(2):294-305.

Hoeger WWK, Bond L, Ransdell L, et al. One-Mile Step Count At Walking And Running Speeds. ACSM Health Fit J. 2008;12(1):14-19.

Goto K, Higashiyama M, Ishii N, Takamatsu K. Prior endurance exercise attenuates growth hormone response to subsequent resistance exercise. Eur J Appl Physiol. 2005;94:333-338.

Janssen Duijghuijsen LM, Mensink M, Lenaerts K, et al. The effect of endurance exercise on intestinal integrity in well-trained healthy men. Physiol Rep. 2016;e12994.

Lac G, Berthon P. Changes in cortisol and testosterone levels and T/C ratio during an endurance competition and recovery. J Sports Med Phys Fitness. 2000;40(2):139-44.

Loucks AB, Thuma JR. Leuteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab. 2003;88(1):297-311.

Mercer JA, Horsch S. Heel-toe running: A new look at the influence of foot strike pattern on impact force. J Exer Sci Fit. 2015;13(1):29-34.

Nieman DC. Post-Exercise Skeletal Muscle Glycogen Related to Plasma Cytokines and Muscle IL-6 Protein Content, But Not Muscle Cytokine MRNA Expression. Front Nutr. 2015.

Scofield KL, Hecht S. Bone Health in Endurance Athletes: Runners, Cyclists, and Swimmers.

Stelzer I, Kröpfl JM, Fuchs R, et al. Ultra-endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function. Scan J Med Sci Sport. 2015;25(5):e442-e450.

Tremblay A, Poehlman ET, Després JP, et al. Endurance training with constant energy intake in identical twins: Changes over time in energy expenditure and related hormones. Metabolism. 1997;46(5):499-503.

Washburn RA, Lambourne K, Szabo AN, et al. Does increased prescribed exercise alter non-exercise physical activity/energy expenditure in healthy adults? A systemic review. Clin Obes. 2014;4(1):1-20.

Adrenal Fatigue: What You Need To Know

Article found here: Adrenal Fatigue: What You Need To Know.

Cadegiani FA, Kater CE. Adrenal fatigue does not exist: a systematic review. BMC Endocrine Disorders. 2016;16:48

Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-62

Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Med. 2017;22(1):96-106

Filipsson H, Monson JP, Koltowska-Haggstrom M, et al. The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. J Clin Endocrinol and Metab. 2006;91:3954–61.
Gupta A, Gupta Y. Glucocorticoid-induced myopathy: Pathophysiology, diagnosis, and treatment. Indian J Endocrinol Metab. 2013;17(5):913–6

Huscher D, Thiele K, Gromnica-Ihle E, et al. Dose-related patterns of glucocorticoid-induced side effects. Ann Rheum Dis. 2009;68(7):1119–24

Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutrition J. 2008;7:11

McDonough AK, Curtis JR, Saag KG. The epidemiology of glucocorticoid associated adverse events. Curr Opin Rheumatol. 2008;20(2):131–7

Oray M, Abu Samra K, Ebrahimiadib N, et al. Long-term side effects of glucocorticoids. Expert Opin Drug Saf. 2016;15(4):457–65

Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol. 1998;50(9):1065-8

Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. JISSN. 2013;10:37

Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. JISSN. 2015;12:43

Wei L, MacDonald TM, Walker BR. Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease. Ann Intern Med. 2004;141:764–70

Whittier X, Saag KG. Glucocorticoid-induced Osteoporosis. Rheum Dis Clin North Am. 2016;42(1):177–89 

Amino Acids: What You Need to Know

Article found here: Amino Acids: What You Need to Know.

Aquilani R, Iadarola P, Contardi A, et al. Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury. Arch Phys Med Rehabil. 2005;86(9):1729-1735

Bach E. Thomsen HH, Johannsen M, et al. Amino acid supplementation is anabolic during the actue phase of endotoxin-induced inflammation: A human randomized crossover trial. J Clin Nutr. 2016;35(2):322-330

Beutheu S, Ouella W, Guérin C, et al. Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats. J Clin Nur. 2014;33(4):694-701

Bellinger PM. Beta-Alanine Supplementation for Athletic Performance: An Update. J Str Cond Res. 2013;28(4)1751-1770

Bendahan D, Mattei JP, Ghattas B, et al. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. 2002;36(4):282-289

Bifari F, Nisoli E. Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view. Brit J Pharm. 2017;174:1366-1377

Brooks N, Cloutier GJ, Cadena SM, et al. Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit. J Appl Physiol. 2008;105(1):241-248

Burd NA, Tang JE, Moore DR, Phillips SM. Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences. J Appl Physiol. 2009;106(5):1692-701

Cole JT, Mitala CM, Kundu S, et al. Dietary branched chain amino acids ameliorate injury-induced cognitive impairment. Proced Nat Acad Sci. 2010;107(1):366-371

Como L, De Siati M, Lorusso F, et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011;77(1):119-22

Galland L. The Gut Microbiome and the Brain. J Med Food. 2014;17(12):1261-1272

Hickner RC, Tanner CJ, Evans CA, et al. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc. 2006;38(4):660-666

Jourdan M, Nair KS, Carter RE, et al. Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet – A pilot study. 2015;34(3):449-456

Laidlaw SA, Shultz TD, Cecchino JT, Kipple JD. Plasma and urine taurine levels in vegans. Am J Clin Nutr. 1988;47(4):66-663

Lainscak M, Filippatos GS, Gheorghiade M, et al. Cachexia: Common, Deadly, With an Urgent Need for Precise Definition and New Therapies. Am J Cardiol. 2008;101[suppl]:8E-10E

Manders RJ, Little JP, Forbes SC, Candow DG. Insulintropic and Muscle Protein Synthetic Effects of Branched-Chain Amino Acids: Potential Therapy for Type 2 Diabetes and Sarcopenia. Nutrients. 2012;4:1664-1678

Ra SG, Miyazaki T, Ishikura K, et al. Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise. JISSN. 2013;10:51 doi:10.1186/1550-2783-10-51

Samocha-Bonet D, Wong O, Synnott EL, et al. Glutamine Reduces Postprandial Glycemia and Augments the Glucagon-Like Peptide-1 Response in Type 2 Diabetes Patients. J Nutr. 2011;141:1233-1238

Taegtmeyer H, Harinstein ME, Gheorghiade M. More Than Bricks and Mortar: Comments on Protein and Amino Acid Metabolism in the Heart. Am J Cardiol. 2008;101[suppl]:3E-7E

Tamanna N, Mahmood N. Emerging Roles of Branched-Chain Amino Acid Supplementation in Human Diseases. Int Schol. Res. Not. 2014

Valerio A, D’Antona G, Nisoli E. Branched-chain amino acids, mitochondrial biogenesis, and health span: an evolutionary perspective. Aging. 2011;3(5):464-478

Antioxidants And Exercise: Why They're Not A Great Combination

Article found here: Antioxidants And Exercise: Why They’re Not A Great Combination

Engelberg J. How Many Pounds Of Oxygen Do We “Eat” Each Day? Am J Physiol. 1996;271:S43-S44.

Peternelj T, Coombes J. Antioxidant Supplementation during Exercise Training. Sports Medicine. 2012;31(12):1043-1069

Phaniendra A, Jestadi DB, Periyasamy L. Free Radicals: Properties, Sources, Targets, And Their Implications In Various Diseases. Indian J Clin Biochem. 2015;30(1):11-26

Are You Going to Get a Flu Shot?

Article found here: Are you going to get a flu shot?

Bambery B, Douglas T, Selgelid MJ, et al. Influenza Vaccination Strategies Should Target Children. Pub Health Ethics. 2017;2(11):221-234.

Center for Disease Control and Prevention. About Flu. Retrieved Sept 30 2019.

Center for Disease Control and Prevention. Flu Vaccine With Adjuvant. Retrieved Oct 2 2019.

Cunningham AS. Official doubletalk hides serious problems with flu shot safety and effectiveness. BMJ. 2018;360:k15.

Demicheli V, Jefferson T, Di Pietrantonj C, et al. Vaccines for preventing influenza in the elderly. Cochrane Systematic Review. 2018:

Demicheli V, Jefferson T, Ferroni E, at al. Vaccines for preventing influenza in healthy adults. Cochrane Systematic Review. 2018:

Eisenstein M. Towards a universal flu vaccine. Nature. 2019;573(7774):S50-S52.

Faked Pandemics – a threat for health. Motion for a recommendation presented by Mr. Wodarg and others. Doc 12110. 18 December 2009.

Jefferson T, Rivetti A, Di Pietrantonj CD, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Systematic Review. 2018:

Jefferson T, Smith S, Demicheli V, Harnden A, Rivetti A, Pietrantonj C. Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet 2005;365(9461):773‐80.

Lipstick M. Challenges of Vaccine Effectiveness and Waning Studies. Clin Inf Dis. 2019;68(10):1631-1633.

McCartney M. Margaret McCartney: What use is mass flu vaccination? BMJ. 2014;349:g6182.

National Health Service. Who should have the flu vaccine. Retrieved Oct 1 2019.

Sarkanen TO, Alkuijala APE, Dauvilliers YA, et al. Incidence of narcolepsy after H1N1 influenza and vaccinations: Systematic review and meta-analysis. Sleep Med Rev. 2018;38:177-186.

Blood Flow Restriction Training: What Is It? How Does It Work?

Article found here: Blood Flow Restriction Training: What Is It? How Does It Work?

Abe T, Kawamoto K, Yasuda T, al. Eight days KAATSU-resistance training improved sprint but not jump performance in collegiate male track and field athletes. Int J KAATSU Train Res. 2005:19-23.

Bagley JR, Rosengarten JJ, Galpin AJ. Is Blood Flow Restriction Training Beneficial for Athletes? Str Cond J. 2015;37(3):48-53.

Cook CJ, Kilduff LP, Beaven CM. Improving strength and power in trained athletes with 3 weeks of occlusion training. Int J Sports Physiol Perform. 2014;9:166-172.

Domingos E, Polito MD. Blood pressure response between resistance exercise with and without blood flow restriction: A systematic review and meta-analysis. Life Sci. 2018;209:122-131.

Hackney KJ, Brown WJ, Stone KA, Tennent DJ. The Role of Blood Flow Restriction Training to Mitigate Sarcopenia, Dynapenia, and Enhance Clinical Recovery. Tech Orthop. 2018;33:98-105.

Hughes L, Paton B, Rosenblatt B, et al. Blood flow restriction training in clinical musculoskeletal rehabilitation: a systematic review and meta-analysis. B J Sports Med. 2017;51(13):1003-1011.

Kubota A, Sakuraba K, Sawaki K, et al. Prevention of disuse muscular weakness by restriction of blood flow. Med Sci Sports Exerc. 2008;40(3):529-34.

Loenneke J, Wilson J, Zourdo M, Bemben M. Low intensity blood flow restriction training: a meta-analysis. Our J Appl Physiol. 2011;112(5):1849-1859.

Manini TM, Vincent KR, Leeuwenburgh CL, et al. Myogenic and proteolytic mRNA expression following blood flow restricted exercise. Acta Physiologica. 2011;201(2):255-263.

Martin-Hernández J, Marín PJ, Menéndez H, et al. Muscular adaptations after two different volumes of blood flow-restricted training. Scand J Med Sci Sports. 2013;23:e114-e120.

Park S, Kim JK, Choi HM, et al. Increase in maximal oxygen uptake following 2-week walk training with blood flow occlusion in athletes. Eur J App Physiol. 2010;109:591-600.

Slysz J, Stultz J, Burr JF. The efficacy of blood flow restricted exercise: A systematic review & meta-analysis. J Sci Med Sport. 2016;19(8):669-675.

Tennent DJ, Hylden CM, Johnson AE, et al. Blood Flow Restriction Training After Knee Arthroscopy: A Randomized Controlled Pilot Study. Clin J Sport Med. 2017;27(3):245-252

Yamanaka T, Farley RS, Caputo JL. Occlusion training increases muscular strength in division IA football players. J Str Cond Res. 2012;26:2523-2529.

Cardiac Cachexia: Symptoms And Strategies To Slow Weight Loss

Article found here: Cardiac Cachexia: Symptoms And Strategies To Slow Weight Loss

Azhar G, Wei JY. New approaches to treating cardiac cachexia in the older patient. Curr Cardiovasc Risk Rep. 2013;7:480–484.

Burks TN, Andres-Mateos E, Marx R, et al. Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia. Sci Transl Med. 2011;3:82ra37.

Cavey J. Cardiac Cachexia. J Nurse Practitioner. 2011;7(7)578-581

Collamati A, Marietta E, Calvani R, et al. Sarcopenia in heart failure: mechanisms and therapeutic strategies. J Geriatr Cardiol. 2016;13:615-624

Caminiti G, Volterrani M, Iellamo F, et al. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol. 2009;54 919–927. 

Carter CS, Giovannini S, Giovaninni S, et al. Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr). 2011;33:167–183.

Iellamo F, Volterrani M, Caminiti G, et al. Testosterone therapy in women with chronic heart failure: a pilot double-blind, randomized, placebo-controlled study. J Am Coll Cardiol 2010;56:1310–1316. 

Jankowska EA, Biel B, Majda J, et al. Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation 2006;114:1829–1837.

Jankowska EA, Filippatos G, Ponikowska B, et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Card Fail 2009;15:442–450.

Malkin CJ, Pugh PJ, West JN, et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J. 2006;27:57–64. 

Marzetti E, Calvani R, DuPree J, et al. Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age (Dordr) 2013;35:1061–1075.

Morley JE. Pharmacologic options for the treatment of sarcopenia. Calcif Tissue Int. 2016;98:319–333.

Onder G, Penninx BWJH, Balkrishnan R, et al. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet (London, England). 2002;359:926–930. 

Sartiani L, Spinelli V, Laurino A, et al. Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers? Clin Cases Miner Bone Metab. 2015;12:135–138.

Stout M, Tew GA, Doll H, et al. Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study. Am Heart J. 2012;164:893–901.

Coffee: Is it good for you?

Article found here: Coffee: Is it good for you?

Arion WJ, Canfield WK, Ramos FC, et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997;339:315–322

Cavin C, Holzhaeuser D, Scharf G, Constable A, Huber WW, Schilter B. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol. 2002;40:1155-63.

Chou T. Wake up and smell the coffee. Caffeine, coffee, and the medical consequences. West J Med. 1992;157(5):544-553

Chu W. Coffee could ward off death and disease, researchers claim. Nutraingredients. July 12 2017. Retrieved July 23 2017.

Church DD, Hoffman JR, LaMonica MB, Riffe JJ, Hoffman MW, et al. The effect of an acute ingestion of Turkish coffee on reaction time and time trial performance. J Int Soc Sports Nutr. 205;12:37 doi:  10.1186/s12970-015-0098-3

Ding M, Bhupathiraju SN, Chen M, et al. Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis. Diabetes Care. 2014;37:569-586

Ding M, Bhupathiraju SN, Satija A, et al. Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies. Circulation. 2014;129(6):643-659

Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol. 1996;144(7):642-644

Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R. Association of Coffee Drinking with Total and Cause-Specific Mortality. N Engl J Med. 2012;366(20):1891-1904

Gavrieli A, Karfopoulou E, Kardatou E, Spyreli E, Fragopoulou E, et al. Effect of Different Amounts of Coffee on Dietary Intake and Appetite of Normal-Weight and Overweight/Obese Individuals. Obesity. 2013;21:1127-1132

Greenberg JA, Boozer CN, Geliebter A. Coffee, diabetes, and weight control. Am J Clin Nutr 2006;84:682–693

Hallström H, Wolk A, Glynn A, Michaëlsson K, Byberg L. Coffee Consumption and Risk of Fracture in the Cohort of Swedish Men (COSM). PLoS One. 2014;9(5):e97770

Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, et al. High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies. Neural Neurosurg Psychiatry. 2016;87:454-460

Hashimoto T, He Z, Ma WY, et al. Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. Cancer Res. 2004;64:3344-9

International Coffee Organization. Trade Statistics Table. Retrieved September 3 2017

Killer SC, Blannin AK, Jeukendrup AE. No Evidence of Dehydration with Moderate Daily Coffee Intake: A Counterbalanced Cross-Over Study in a Free-Living Population. PLoS One. 2014;9(1):e84154 doi: 10.1371/journal.pone.0084154

Lacerda SA, Matuoka RI, Macedo RM, Petenusci SO, Campos AA, Brentegani LG. Bone Quality Associated with Daily Intake of Coffee: A Biochemical, Radiographic and Histometric Study. Branz Dent J. 2010;21(3):199-204

Larsson SC. Coffee, Tea, and Cocoa and Risk of Stroke. Stroke. 2014;45(1):309:314

Lee WJ, Zhu BT. Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 2006;27:269-77.

Li Shuai, Zhipeng D, Qiang W. Effect of coffee intake on hip fracture: a meta-analysis of prospective cohort studies. Nutrition J. 2015;14:38 doi: 10.1186/s12937-015-0025-0

Lipworth L., Sonderman J.S., Tarone R.E., McLaughlin J.K.: Review of epidemiologic studies of dietary acrylamide intake and the risk of cancer. Eur J Cancer Prev. 2012; 21(4): 375-386.

Liu F, Wang X, Wu G, Chen L, Hu P, et al. Coffee Consumption Decreases Risks for Hepatic Fibrosis and Cirrhosis: A Meta-Analysis. PlOS One. 10(11): e0142457. doi: 10.1371/journal.pone.0142457

Liu J, Shen B, Shi M, Cai J. Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study. PLoS One. 2016;11(1):e0147056

Lucas M, Mirzaei F, Pan A, Okereke OI, Willet WC, et al. Coffee, Caffeine, and Risk of Depression Among Women. Arch Intern Med. 2011171(17):1571-1578 doi: 10.1001/archinternmed.2011.393.

Mark Pendergrast. Uncommon Grounds: The History of Coffee and How it Trasnformed Our World. 2010 Basic Books. Philadelphia, PA 19103

Martini D, Del Bo, C, Tassotti M, Riso P, Del Rio D. Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies. Molecules. 2016;21:979 doi: 10.3390/molecules21080979

Maughan RJ, Griffin J. Caffeine ingestion and fluid balance: a review. J Hum Nutr Diet. 2003;16(6):411-20

National Coffee Association USA. The History of Coffee. Retrieved September 3 2017

Pop Culture. 1992 Trivia, Facts & History. Retrieved September 2 2017

Porta M, Vioque J, Ayude D, et al. Coffee drinking: the rationale for treating it as a potential effect modifier of carcinogenic exposures. Eur J Epidemiol. 2003;18:289-98.

Rice J.M.: The carcinogenicity of acrylamide. Mutation Research. 2005; 580: 3-20.

Richardson DL, Clarke ND. Effect of Coffee and Caffeine Ingestion on Resistance Exercise Performance. J Strength Cond Res. 2016;30(10):2892-900

Shen L. Letter: gut microbiota modulation contributes to coffee’s benefits for non-alcoholic fatty liver disease. Aliment Pharmacol Therap. 2014;39(12):1441-1442

Shimamoto T, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M, et al. No Association of Coffee Consumption with Gastric Ulcer, Duodenal Ulcer, Reflux Esophagitis, and Non-Erosive Reflux Disease: A Cross-Sectional Study of 8,013 Healthy Subjects in Japan. PLoS One. 2013;8(6):e65996 doi:  10.1371/journal.pone.0065996

Shukitt-Hale B, Miller MG, Chu YF, Lyle BJ, Joseph JA. Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. AGE. 2013;35:2183-2192

Starbucks. Starbucks Company Timeline. Retrieved September 2 2017

The Statistics Portal. Coffee production worldwide from 2003/04 to 2017/17 (in million 60 kilogram bags). Retrieved September 3 2017

Svilaas A, Sakhi AK, Andersen LF, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 2004;134:562–567

Thong FS, Graham TE. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J Appl Physiol (1985) 2002;92:2347–2352

Trexler ET, Smith-Ryan AE, Roeiofs EJ, Hirsch KR, Mook MG. Effects of coffee and caffeine anhydrous on strength and sprint performance. Eur J Sport Sci. 2016;16(6):702-710

Urgert R, Katan MB. The cholesterol-raising factor from coffee beans. Annu Rev Nutr. 1997;17:305–324.

van Dam RM. Coffee and type 2 diabetes: from beans to beta-cells. Nutr Metab Cardiovasc Dis 2006;16:69–77

van Dam RM. Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Appl Physiol Nutr Metab 2008; 33:1269–1283

van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RM. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care 2009;32:1023–1025

WHO. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal; International Agency for Research on Cancer: Lyon, France, 1991.

Wilson K.M., Giovannucci E., Stampfer M.J., Mucci L.A.: Dietary acrylamide and risk of prostate cancer. Int J Cancer. 2012; 131(2): 479-487.

Wierzejska R. Coffee Consumption vs Cancer Risk – A Review of Scientific Data. Rocz Panstw Zakl Hig. 2015;66(4):293-298

Yes A, Yilmaz Y. Review article: coffee consumption, the metabolic syndrome and non-alcoholic fatty liver disease. Alimen Pharmacy Therap. 2013;38(9):1038-1044

Zeng SB, Weng H, Zhou M, Duan XL, Shen XF, Zeng XT. Long-Term Coffee Consumption and Risk of Gastric Cancer: A PRISMA-Complian Dose-Response Meta-Analysis of Prospective Cohort Studies. Med. 2015;94(38):e1640 doi: 10.1097/MD.0000000000001640

Zhou Q, Luo ML, Li H, Li M, Zhou JG. Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies. Sci Rep. 2015;134:10 doi: 10.1038/srep13410.

Collagen: Health Benefits and How to Supplement With Collagen Peptides

Article found here: Collagen: Health Benefits and How to Supplement With Collagen Peptides

Adam M. Therapie Der Osteoarthrose – Welche Wirkung Haben Gelantineparaprate? Therapiewoche. 1991;41:2456-2461.

Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006;22(11)2221-32.

Chiang TL, Chang IG, Lee HH, et al. Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate. Int J Med Sci. 2016;13(11):853-857.

Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008;24(5):1485-1496.

Cúneo F, Costa-Paiva L, Pinto-Neto AM, et al. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Maturitas. 2010;65(3):253-257.

Czajka A, Kania EM, Genovese L, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018;57:97-108.

Hong H, Fan H, Chalamaiah M, Wu, J. Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives. Food Chem. 2019;301:125222.

Hopkinson I. Molecular components of the extracellular matrix. J Wound Care. 1992;1(1):52-54.

Hou IC, et al. Effects of a Food Containing Chicken Collagen Hydrolysate on Blood Pressure and Vascular Endothelial Function in Subjects with High—normal Blood Pressure and StageⅠ Hypertension ―A Randomized, Double—blind, Parallel—group, Placebo—controlled Trial. 薬理と治療. 2017;45:1333-1343.

Igase M, Kohara K, Okada Y, et al. A double-blind, placebo-controlled, randomised clinical study of the effect of pork collagen peptide supplementation on atherosclerosis in healthy older individuals. Biosci, Biotech, Biochem. 2018:1-3

Kim DU, Chung HC, Choi J, et al. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. 2018;10(7):826.

Liu J, Wang Y, Song S, et al. Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PLoS One. 2015;10(8):e0135019.

Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Sem Arth Rheum. 2000;30(2):87-99.

Nieuwenhuizen AG, Hochstenbach-Waelen A, Veldhorst MA, et al. Acute effects of breakfasts containing alpha-lactalbumin, or gelatin with or without added tryptophan, on hunger, ‘satiety’ hormones and amino acid profiles. Br J Nutr. 2009;101(12):1859-66.

O’Keefe MB, Norris R, Alahi MA, et al. Peptide identification in a porcine gelatin propel endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity. J Fun Foods. 2017;34:77-88.

Sanchez A, Blanco M, Correa B, et al. Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture. Mar Drugs. 2018;16(5):144.

Sato K. The presence of food-derived collagen peptides in human body-structure and biological activity. Food Funct. 2017;8:4325.

Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015;18(12):1340-8.

Veldhorst MA, Nieuwenhuizen AG, Hochstenbach-Waelen A, et al. A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clin Nutr. 2009;28(2):147-55.

Zdzieblik D, Oesser S, Baumstark M, et al. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenia men: A randomised controlled trial. Brit J Nut. 2015;114(08):1237-1245.

Zdzieblik Dosser S, Golhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017;42(6):588-595.

Zhang Y, Stefanovic B. LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. Int J Mol Sci. 2016;17(3):419.

Delayed Onset Muscle Soreness (DOMS): What it is. How to get rid of it.

Asmussen E. Observations on experimental muscle soreness. Acta Rheumatol Scand. 1956;2:109-116.

Bobbert MH, Hollander AP, Huijing PA. Factors in delayed onset muscular soreness of man. Med Sci Sports Exerc. 1986;18(1):75-81.

Cheatham SW, Kolber MJ, Cain M, Lee M. The Effects of Self-Myofascial Release Using A Foam Roll Or Roller Massager On Joint Range Of Motion, Muscle Recovery, And Performance: A Systematic Review. Int J Sports Phys Ther. 2015;10(6):827-838.

Cheung K, Hume P, Maxwell L. Delayed Onset Muscle Soreness. Sport Med. 2012;33(2):145-164.

Cooper SM. The Effects of Compression Garments on Recovery. J Strength Cond Res. 2009;23(6):1786-1794.

Costerllo JT, Algar LA, Donnelly AE. Effects of whole-body cryotherapy (-110 ºC) on proprioception and indices of muscle damage. Scan J Med Sci Sport. 2012;22(2):190-198.

de Vries HA, Electromyographic observations of the effects of static stretching upon muscular distress. Res Q. 1961;32:468-479.

Drobnic F, Riera J, Appendino G, et al. Reduction of delayed onset muscle soreness by a novel delivery system (Meriva®): a randomised, placebo-controlled trial. J Int Soc Sports Nutr. 2014;11:31.

Erten YT, Sahinkaya T, Dine E, Kilinc BE, Bayraktar B. The effects of compression garments and electrostimulation on athletes’ muscle soreness and recovery. J Exerc Rehab. 2016;12(4):308-313.

Gulick DT, Kimura IF, Sitler M, et al. Various treatment techniques on signs and symptoms of delayed muscle soreness. J Athletic Train. 1996;31(2):145-152.

Hasson SM, Daniels JC, Divine JG, et al. Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. Med Sci Sports Exerc. 1993;25(1):9-17.

Hewlings SJ, Kalman DS. Curcumin: A Review of Its’ Effect on Human Health. Foods. 2017;6(10):92.

Hurley CF, Hatfield DL, Riebe DA. The Effect of Caffeine Ingestion on Delayed Onset Muscle Soreness. J Str Cond Res. 2013;27(11):3101-3109.

Johar P, Grover V, Topp R, Behm DG. A comparison of Topical Menthol To Ice on Pain, Evoked Tetanic and Voluntary Force During Delayed Onset Muscle Soreness. Int J Sports Phys Ther. 2012;7(3):314:322.

Kim J, Lee J. A review of nutritional intervention on delayed onset muscle soreness. Part I. J Exerc Rehab. 2014;10(6):349-356.

Kloth L. Electrotherapeutic alternative for the treatment of pain. In: Gersh M, editor. Electrotherapy in rehabilitation. Philadelphia (PA): Davis, 1992:197-217.

Lambert MI, Marcus P, Burgess T, et al. Electro-membrane micro current therapy reduces signs and symptoms of muscle damage. Med Sci Sports Exerc. 2002;34(4):602-607.

Na HS, Ryu JH, Do SH. The role of magnesium in pain. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.

Nicoletta G, Mannelli DC, Lorenzo DCM, Gabriela M, et al. Menthol: a natural analgesic compound. Neuroscience Letters. 2002;322(3).

NIH U.S. National Library of Medicine. Menthol. Acquired March 10 2019. Menthol | C10H20O – PubChem

Pearcey GE, Bradbury-Squires DJ, Kawamoto JE, et al. Foam Rolling for Delayed-Onset Muscle Soreness and Recovery of Dynamic Performance Measures. J Athl Train. 2015;50(1):5-13.

Schmitz RJ, Martin DE, Perrin DH, et al. Effect of interferential current on perceived pain and serum cortisol associated with delayed onset muscle soreness. J Sport Rehabil. 1997;6:30-37.

Schwane JA, Hatrous BG, Johnson SR, et al. Is lactic acid related to delayed-onset muscle soreness? Phys Sports Med. 1983;11(3):124-127, 130-131.

Stevens C, Best R. Menthol: A Fresh Ergogenic Aid For Athletic Performance. Sport Med. 2016;47(6).

Tanabe Y, Maeda S, Akazawa N, et al. Attentuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol. 2015;115(9):1949-1957.

Digestive Enzymes: What You Need to Know

Read article here: Digestive Enzymes: What You Need to Know.

Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee—a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-5.

Anon. Oral enzyme therapy in osteoarthritis of the knee. Proteolytic enzyme are effective with few risks. MMW Fortschr Med. 2001;143(23):44-6

Corazza GR, Benati G, Sorge M, et al. beta-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study. Aliment Pharmacol Ther. 1992;6:61-6.

Deng Y, Misselwitz B, Dai N, Fox M. Lactose Intolerance in Adults: Biological Mechanism and Dietary Management. Nutrients. 2015;7:8020-8035 doi:10.3390/nu7095380

Di Stefano M, Miceli E, Gotti S, et al. The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. Dig Dis Sci. 2007;52:78-83.

Duskova M, Wald M. Orally administered proteases in aesthetic surgery. Aesthetic Plast Surg. 1999;23(1):41-4

Ganiats TG, Norcross WA, Halverson AL, Burford PA, Palinkas LA. Does Beano prevent gas? A double-blind crossover study of oral alpha-galactosidase to treat dietary oligosaccharide intolerance. J Fam Pract 1994;39:441-5.

Gaspani L, Limiroli E, Ferrario P, Bianchi M. In vivo and in vitro effects of bromelain on PGE2 and SP concentrations in the inflammatory exudate in rats. Pharmacology. 2002;65:83-6.

Janssen G, Christis C, Kooy-Winkelaar Y, et al. Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements. PLOSone. 10(6):e0128065

Johnson LR, ed. Physiology of the Gastrointestinal Tract. Fourth edition. Boston: Elsevier Academic Press; 2006.

Kamenicek V, Holan P, Franek P. Systemic enzyme therapy in the treatment and prevention of post-traumatic and postoperative swelling. Acta Chir Orthop Traumatol Cech. 2001;68(1):45-9

Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes: a randomised, double-blind study versus diclofenac. Clin Drug Invest 2000;19:15-23.

Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30.

Laugier R, Bernard JP, Berthezene P, Dupuy P. Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion. 1991;50(3-4):202-11.

Leipner J, Iten F, Saller R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs. 2001;15(12):779-89

Lin MY, Dipalma JA, Martini MC, et al. Comparative effects of exogenous lactase (beta-galactosidase) preparations on in vivo lactose digestion. Dig Dis Sci. 1993;38:2022-7.

Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol. 2013;19(42):7258-66

Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine.2002;9:1-6.

National Institute of Diabetes and Digestive and Kidney Diseases. Digestive Diseases Statistics for the United States. Retrieved July 8 2017

Srimanjari K, Nagalla B, Abbagani V, et al. Role of Proteases and Antiprotease in the Etiology of Pancreatitis. Saudi J Gastroenterol. 2012;18(6)364-368

Struyvenberg MR, Martin CR, Freedman SD. Practical guide to exocrine pancreatic insufficiency – Breaking the myths.  BMC Medicine. 2017;15:29

Do Detox Diets Work?

Article found here: Do Detox Diets Work?

Aga M, Iwaki K, Ueda Y, et al. Preventative effect of /Coriandrum sativum/ (Chinese parsley) on localized lead deposition in ICR mice. J Ethanopharmacol. 2001;77:203-208.

Anzenbacher P, Anzenbacherova E. Cytochromes P450 and metabolism xenobiotics. Cell Mol Life Sci. 2001;58:737-747.

Bisanz JE, Enos MK, Mwanga JR, et al. Randomized Open-Label Pilot Study of the Influence of Probiotics and the Gut Microbiome on Toxic Metal Levels in Tanzanian Pregnant Women and School Children. mBio. 2014;5(5). Doi:10.1128/mBio.01580-14.

Cai L, Wan D, Yi F, Luan L. Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root. Molecules. 2017;22(9):1409.

CDC. Understanding Thimerosal, Mercury, and Vaccine Safety. Retrieved Jan 27 2019.

Chemical Safety Facts. Debunking the Myths: Are there really 84,000 chemicals? Retrieved January 15 2019.

Cline JC. Nutritional Aspects of Detoxification in Clinical Practice. Alt Therap. 2015;21(3):54-62.

Cosmetics. Phthalates. U.S. Food & Drug Administration website. Retrieved January 15 2019. Phthalates.

Cutler N. January detox diets might actually hurt your liver, warns health adviser. Nutra Ingredients. January 4 2019. Retrieved January 15 2019. January detox diets might actually hurt your liver, warns health adviser.

Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Current Drug Metabolism. 2002;3(6):561-597.

Domingo JL, Gomez M, Llobet JM, et al. Citric, malic, and succinc acids as possible alternatives to deferoxamine in aluminum toxicity. J Toxicol Clin Toxicol. 1988;26;67-79.

EFSA. Safety of aluminum from dietary intake: scientific opinion of the panel on food additives, flavourings, processing aids and food contact materials. EFSA J. 2008;754;1-34.

Egner PA, Chen JG, Zarth AT, et al. Rapid and Sustainable Detoxification of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China. Cancer Prev Res. doi: 10.1158/1940-6207.CAPR-14-0103.

Evans SA, Parsons AD, Overton JM. Homeostatic responses to caloric restriction: influence of background metabolic rate. J Appl Physiol. 2005;99(4)1336-1342.

Gargouri M, Ghorbel-Koubaa F, Bonenfant-Magné M, et al. Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain cerebellum of newborn rats. Food Chem Toxicol. 2012;50(7):2302-2310.

Hodges RE, Minisch DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutra Metab. 2015:760689.

Jones KC, De Voogt P. Persistent organic pollutants (POPs): state of the science. Environ Pollut. 1999;100:209-221.

Karkos PD, Leong SC, Karkos CD, et al. Spirulina in Clinical Practice: Evidence-Based Human Applications. Evid Based Complement Alternat Med. 2011:531053.

Kay VR, Chambers C, Foster WG. Reproductive and developmental effects of phthalate dieters in females. Crit Rev Toxicol. 2013;43:200-219.

Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. 2015;28(6):675-686.

Kouda K, Nakamura H, Kohno H, et al. Metabolic response to short-term 4-day energy restriction in a controlled study. 2008;11(2):89-92.

Liu Q, Zhao H, Gao Y, et al. Effects of Dandelion Extract on the Proliferation of Rat Skeletal Muscle Cells and the Inhibition of a Lipopolysaccharide-Induced Inflammatory Reaction. Chin Med J. 2018;131(14):1724-1731.

Newbold RR, Jefferson WN, Padilla-Banks E. Long-term adverse effects of neonatal exposure to bisphenol A on the maurine female reproductive tract. Reprod. Toxicol. 2007;24:253-258.

Pellegrini L, Belcaro G, Dugall M, et al. Supplementary management of functional, temporary alcoholic hepatic damage with Robust® (French oak wood extract). Minerva Gastroentero. Diet. 2016;62(3):245-252.

Porta M, Zumeta E. Implementing the Stockholm treaty on persistent organic pollutants. Occup Environ Med. 2002;59;651-652.

Ren H, Jia H, Kim S, et al. Effect of Chinese parsley /Coriandrum sativum/ and chitosan on inhibiting the accumulation of cadmium in cultured rainbow trout /Oncorhynchus/. Fish Sci. 2006;72:263-269.

Ruma Arora S, Sudhakar K, Rana RS. Spirulina – From growth to nutritional product: A review. Trends in Food Sci Tech. 2017;69:151-171.

Ruzzin J, Lee D-H, Carpenter DO, et al. Reconsidering metabolic diseases: the impacts of persistent organic pollutants. Atherosclerosis. 2012;224:1-3.

Saha SK, Misbahuddin M, Ahmed AU. Comparison between the effects of alcohol and hexane extract of spirulina in arsenic removal from isolated tissues. Mymensingh Med J. 2010;19(1):27-31.

Schettler T. Human exposure to phthalates via consumer products. Int J Androl. 2006;29:134-139.

Stockholm Convention. Stockholm Convention On Persistent Oranic Pollutants.

Uchikawa T, Ueno T, Hasegwa T, et al. Parachlorella beijerinkii acceleraties lead excretion in mice. Toxicicol Ind Health. 2009;25:551-556.

von Saal FS, Myers JP. Bisphenol A and risk of metabolic disorders. JAMA. 2008;300-1353-1355.

Wang L, Min M, Li Y, et al. Cultivation of green algae Chlorella sp. in different wastewater from municipal wastewater treatment plant. Appl Biochem Biotechnol. 2010;162;1174-1186.

Zhang Y, Liu C, Zhao Y, et al. The Effects of Calorie Restriction in Depression and Potential Mechanisms. Curr Neuropharmacol. 2015;13(4):536-542.

Essential Oils For Fitness: Research, Anecdotal Evidence, Experimentation

Article found here: Essential Oils For Fitness: Research, Anecdotal Evidence, Experimentation

Atsumi T, Tonosaki K. Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva. Psychiatry Res. 2007;150(1):89-96.

Ceccarelli I, Lariviere WR, Fiorenzani P. Effects of long-term exposure of lemon essential oil odor on behavioral, hormonal and neuronal parameters in male and female rats. Brain Res. 2004;1001(1-2):78-86.

Cho JH, Kim HJ, Kim IH. Effects of phytogenic feed additive on growth performance, digestibility, blood metabolites, intestinal microbiota, meat color and relative organ weight after oral challenge with Clostridium perfringens in broilers. Livest. Sci. 2014;160:82–88. 10.1016/j.livsci.2013.11.006.

Choi SY, Kang P, Lee HS, Seol GH. Effect of Inhalation of Essential Oil of Citrus uranium I. var. amara on Menopausal Symptoms, Stress, and Estrogen in Postmenopausal Women: A Randomized Controlled Trial. Evid Bas Compl Altern Med. 2014.

Di Pasqua R, Betts G, Hoskins N, et al. Membrane toxicity of antimicrobial compounds from essential oils. J. Agric. Food Chem. 2007;55:4863–4870. 10.1021/jf0636465.

Ford AC, Talley NJ, Moayyedi P. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ. 2008;337:a2313.

Goel N, Kim H, Lao RP. An olfactory stimulus modifies nighttime sleep in young men and women. Chronobiol Int. 2005;22(5):889-904.

Hawkins J, Hires CY, Dunne EW, Keenan LA. Aromatherapy reduces fatigue among women with hypothyroidism: A randomized placebo-controlled clinical trial. J Compl Int Med. 2019.

Haze S, Sakai K, Gozu Y. Effects of Fragrance Inhalation on Sympathetic Activity in Normal Adults. Jpn J Pharmacol. 2002;90:247-253.

Hawrelak JA, Cattley T, Myers SP. Essential Oils in the Treatment of Intestinal Dysbiosis: A Preliminary in vitro Study. Alt Med Rev. 2009;14:4:380-384.

Höferl M, Hütter C, Buchbauer G. A Pilot Study on the Physiological Effects of Three Essential Oils in Humans. Natural Product Communications. 2019;11(10):4.

Hotta M, Nakata R, Katsukawa M, et al. Caracol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression. J Lipid Res. 2010;51(1):132-139.

Ju MS, Lee S, Bae I, et al. Effects of Aroma Massage on Home Blood Pressure, Ambulatory Blood Pressure, and Sleep Quality in Middle-Aged Women with Hypertension. Evid Bas Compl Alt Med. 2013;403251.

Judzentiene A, Kupcinskiene E. Chemical composition on essential oils from needles of Pinus sylvestris L. grown in Northern Lithuania. J Essent Oil Res 2008;20:26-29.

Karadag E, Samancioglu S, Ozden D, Bakir E. Effects of aromatherapy on sleep quality and anxiety of patients. Nurs Crit Care. 2017;22(2):105-112.

Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behav Brain Res 2006;172:240–249.

Komori T, Matsumoto T, Motomura E, Shiroyama T. The Sleep-Enhancing Effect of Valerian Inhalation and Sleep-Shortening Effect of Lemon Inhalation. Chem Senses. 2006;31:731-737.

Lid D, et al. Microcapsule of sweet orange essential oil changes gut microbiota in diet-induced obese rats. Biochem Biophys Res Commun. 2018.

Lillehei AS, Halcon LL. A systematic review of the effect of inhaled essential oils on sleep. J Altern Complement Med. 2014;20(6):441-51.

Lillehei AS, Halcón LL, Savik K, Reis R. Effect of Inhaled Lavender and Sleep Hygiene on Self-Reported Sleep Issues: A Randomized Controlled Trial. J Altern Complement Med. 2015;21(7):430-438.

Logan AC, Beaulne TM. The Treatment of Small Intestinal Bacterial Overgrowth With Enteric-Coated Peppermint Oil: A Case Report. Alt MEd Rev. 2002;7(5):410-417.

Matsubara E, Tsunetsugu Y, Ohira T, Sugiyama M. Essential Oil of Japanese Cedar (Cryptomeria japonica) Wood Increases Salivary Dehydroepiandrosterone Sulfate Levels after Monotonous Work. Int J Environ Res Public Health. 2017;14(1):97.

Meamarbashi A. Instant effects of peppermint essential oil on physiological parameters and exercise performance. Avicenna J Phytomed. 2014;4(1):72-78.

McDonnell B, Newcomb P. Trial of Essential Oils to Improve Sleep for Patients in Cardiac Rehabilitation. J Altern Complement Med. 2019;26; doi: 10.1089/acm.2019.0222.

Modak T, Mukhopadhaya A. Effects of citral, a naturally occurring antiadipogenic molecule, on an energy-intense diet model of obesity. Indian J Pharmacol. 2011;43(3):300-305.

Moss M, Hewitt S, Moss L, Wesnes K. Modulation of cognitive performance and mood by aromas of peppermint and ylang-ylang. Int J Neurosci. 2008;118(1):59-77.

Shinohara K, Doi H, Kumagai C, Dawano E, Tarumi W. Effects of essential oil exposure on salivary estrogen concentration in perimenopausal women. Neuroendocrin Lett. 2016;35(8)567-572.

Sönmez GT, Çolak M, Sönmez S, Schoenfeld B. Effects of oral supplementation of mint extract on muscle pain and blood lactate. Biomes Hum Kin. 2010;2:66-69.

Stohs Sj, Preuss HG, Shara M. A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. Int J Med Sci. 2012;9:527-538.

Today M, Morimoto K. Effect of lavender aroma on salivary endocrinological stress markers. Arch Oral Biol. 2008;53(10):964-8.

Toden S, Theiss AL, Wang X, Noel A. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis. Sci Rep. 2017;7:814.

Umezu T. Evidence for dopamine involvement in ambulation promoted by pulegone in mice. Pharmacol Biochem Behav 2010;94:497–502.

Varney E, Buckle J. Effect of inhaled essential oils on mental exhaustion and moderate burnout: a small pilot study. J Altern Complement Med. 2013;19(1):69-71.

Wang S, Wang C, Peng D. Agarwood Essential Oil Displays Sedative-Hypnotic Effects through the GABAergic System. Molecules. 2017;22(12): pii: E2190.

Watanabe E, Kuchta K, Kimura M, et al. Effects of Bergamot (Citrus bergamia (Risso) Wright & Arn.) Essential Oil Aromatherapy on Mood States, Parasympathetic Nervous System Activity, and Salivary Cortisol Levels in 41 Healthy Females. Compl Med Res. 2015;22(1).

Woo J, Yang H, Yoon M, et al. 3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABAA-benzodiazepine Receptors. Experiment Neurobio. 2019;28(5):593-601.

Wu Y, Zhang Y, Xie G, et al. The Metabolic Responses to Aerial Diffusion of Essential Oils. PLoS ONE. 2012;7(9):e44830.

Yang H, Woo J, Pae AN, et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. 2016;90(5):530-539.

Yuan L, Xiongfeng F, Ma X, et al. Intestinal Microbiome-Metabolome Responses to Essential Oils in Piglets. Front Micobiol. 2018;9;1988

Fish Oil: Why Your Body And Brain Benefit From Supplementing With Omega-3s

Article found here: Fish Oil: Why Your Body And Brain Benefit From Supplementing With Omega-3s

Bouwens M. van de Rest 0, Dellschaft N, et al. Fish-oil supplementation induces anti-inflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009;90(2):415-424

Chilton FH, Dutta R, Reynolds LM, et al. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 2017;9)1):1165. doi: 10.3390/nu9111165.

Davis W. Why does fish oil reduce triglycerides? The Heart Scan Blog. November 1, 2009

Du S, Jin J, Fang W, Su Q. Does Fish Oil Have an Anti-Obesity Effect in Overweight/Obese Adults? A Meta-Analysis of Randomized Controlled Trials. PLoS ONE 10(11): e0142652. doi:10.1371/journal.pone.0142652.

Firlag M, Kamaszewski M, Adamek D, et al. Long-term consumption of fish oil partially protects brain tissue from age-related neurodegeneration. Postepy High Med Dosw. 2015;69:188-196.

Furuhjelm C, Warstedt K, Larsson J, et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatrica 2009

Gidding SS, Prospero C, Hossain J., et al. A Double-Blind Randomized Trial of Fish Oil to Lower Triglycerides and Improve Cardiometabolic Risk in Adolescents. J Pediatr. 2014;165(3):497-503.

Gurzell EA, Teague H, Harris M. et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. Journal of Leukocyte Biology, 2012; 93 (4): 463 DOI: 10.1189/jlb.0812394.

Joensen A, Schmidt E, Dethlefsen C, et al. Dietary intake of total marine n-3 polyunstaurated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome – a cohort study. Br J Nutr. 2010;103(4):602-7.

Kim M, Goto T, Yu R, et al. Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system. Sci Rep. 2015;5:18013. 10.1038/srep18013.

Micallef M, Munro I, Garg M. An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. E J Clin Nutr. 2009:63;1154-1156.

Micallef M, Munro I, Phang M, Garg M. Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity. Br J Nutr. 2009;102(9):1370-1374. Omega-3 awareness not backed by supplement choices: Survey. Sept 25, 2009.

Parra D, Ramel A, Bandarra N, et al. A diet rich in long chain omega-3 fatty acids modulates satiety in overweight and obese volunteers during weight loss. Appetite. 2008;51(3):676-680.

Perricone, N. The Perricone Weight Loss Program. LE Magazine. November, 2005.

Pipingas A, Cockerell R, Grima N, et al. Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells. Nutrients. 2014;6:1956-1970.

Qin Y, Zhou Y, Chen SH, et al. Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. PLoS One. 2015;10(7):e0133496. doi: 10.1371/journal.pone.0133496.

SanGiovanni J, Agron E, Meleth AD, et al. w-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: a prospective cohort study from the Age-Related Eye Disease Study. Am J Clin Nutr. 2009;90(6):1601-7.

Smith GI, Atherton P, Reeds DN, et al. Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperaminoacidemia-hyperinsulinemia in healthy young and middle aged men and women. Clin Sci (Long.) 2011;12(6):267-278

Smith GI, Julliand S, Reeds DN. et al. Fish oil–derived n–3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015;102:115–22

Ulven SM, Holven KB. Comparison of bioavailability of krill oil versus fish oil and health effect. Vascular Health and Risk Management. 2015:11;511–524.

Whalen J. Probing Health Benefits from Eating Omega-3s. The Wall Street Journal. Sept 14, 2009.

Glutathione: Health Benefits And How To Raise Your Levels

Article found here: Glutathione: Health Benefits And How To Raise Your Levels

Arjinpathana N, Asawanonda P. Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. J Dermatolog Treat. 2012;23(2):97–102.

Bahadoran Z, Mirmiran P, Hosseinpanah F, et al. Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. Eur J Clin Nutr. 2011;65(8):972-977.

Bogaards JJ, Verhagen H, Willems MI, et al. Consumption of Brussels sprouts results in elevated alpha-class glutathione S-transferase levels in human blood plasma. Carcinogenesis. 1994;15(5):1073-1075.

Bumrungpert A, Pavadhgul P, Nunthanawanich P, et al. Whey Protein Supplementation Improves Nutritional Status, Glutathione Levels, and Immune Function in Cancer Patients: A Randomized, Double-Blind Controlled Trial. J Med Food. 2018;21(6):612-616.

Campolo J, Bernardi S, Cozzi L, et al. Medium-chain effect of sublingual L-glutathione supplementation on flow-mediated dilation in subjects with cardiovascular risk factors. Nutrition. 2017;38:41-47.

Deponte M. The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures? Antioxid Redox Signal. 2017;27(15)1130-1161.

Halpner AD, Handelman GJ, Harris JM, et al. Protection by vitamin C of loss of vitamin E in cultured rat hepatocytes. Arch Biochem Biophys. 1998;359:305-309.

Handog EB, Datuin MS, Singzon IA. An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women. Int J Dermatol. 2016;55(2):153–157.

Kalaras MD, Richie JP, Calcagnotto A, Beelman RB. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chem. 2017;233:429-433.

Li X, Qu ZC, May JM. GSH is required to recycle ascorbic acid in cultured liver cell lines. Antioxid Redox Signal. 2001;3:1089-1097.

Montecinos V, Guzmán P, Barra V, et al. Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione. J Biol Chem. 2007;282:15506-15515.

Moore LE, Brennan P, Karami S, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in Central and Eastern European Cancer Study. Carcinogenesis. 2007;28(9):1960-1964.

Nuttall SL, Martin U, Sinclair AJ, Kendall MJ. Glutathione: In sickness and in health. The Lancet. 1998; 351:645-646/

Park EY, Shimura N, Konishi T, et al. Increase in the protein-bound form of glutathione in human blood after the oral administration of glutathione. J Agric Food Chem. 2014;62(26):6183–6189.

Schmitt B, Vicenzi M, Garrel C, Denis FM. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015;6:198-205.

Sinha R, Sinha I, Calcagnotto A, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018;72(1):105-111.

Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmaco. 2003;57(3):145-155.

Watanabe F, Hashizume E, Chan GP, Kamimura A. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol. 2014;7:267–274.

Yao DF, Mills JN. Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian J Androl. 2016;18(3):410-418.

Zitka O, Skalickova S, Gumulec J, et al. Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. Oncol. Lett. 2012;4(6):1247-1253.

Gluten and Going Gluten-Free: What You Need to Know

Article found here: Gluten and Going Gluten-Free: What You Need to Know.

Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-514

Catassi C. Gluten Sensitivity. Ann Nutr Metab. 2015;65(suppl 2):16-26

Ciaccio EJ, Lewis SK, Biviano AB, et al. Cardiovascular involvement in celiac disease. World J Cardiol. 2017;9(8):652-666

Ferretti G, Bacchetti T, Masciangelo S, Saturni L. Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenic Approach. Nutrients. 2012;4:243-257

Garg K, Agarwal P, Gupta RK, Sitaraman S. Joint Involvement in Children with Celiac Disease. Indian Pediatr. 2017;15;54(11):946-948

Guandalini S. A Brief History of Celiac Disease. Impact: University of Chicago Celiac Disease Center. 2017;7(3)

Igbinedion SO, Ansari J, Vasikaran A, et al. Non-celiac gluten sensitivity: All wheat attack is not celiac. World J Gasteroenterol 2017;23(40):7201-7210

Janssen G, Christis C, Kooy-Winkelaar Y, et al. Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements. PLoS. 2015;10(6):e1028065

Leccioli V, Oliveri M, Romeo M, et al. A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence. Nutrient. 2017;9:1203

Luo EK. What happens in gluten ataxia? Medical News Today Jan 2018. Retrieved March 11 2018.

Mayo Clinic. Celiac disease. Retrieved March 11 2018

Mingomataj EC, Gjata E, Bakiri A, et al. Gliadin allergy manifested with chronic urticaria, headache and amenorrhea. BMJ Case Rep. 2011: bcr1020114907

Olafsen T. Solved the riddle of coeliac disease. UiO Institute of Clinical Medicine. 2015. Retrieved March 12 2018

Pennisi M, Bramanti A, Cantone M, et al. Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections. Front Neurosci. 2017;11:498 doi: 10.3389/fnins.2017.00498

Sapone A, Baj JC, Ciacci C, et al. Spectrum of gluten disorders: consensus on new nomenclature and classification. BMC Med. 2012;10:13 1. 

Gluten Consumption, Babies, and the Risk of Type I Diabetes

Article found here:

American Diabetes Association. Statistics About Diabetes. Retrieved Sept 19 2019.

Bullard KM, Cowie CC, Lessem SE, et al. Prevalence of Diagnosed Diabetes in Adults by Diabetes Type – United States, 2016. Center for Disease Control and Prevention. March 30, 2018. Retrieved Sept 19 2019.

Diabetologia. Child’s gluten intake during infancy, rather than mother’s during pregnancy, linked to increased risk of developing type 1 diabetes. ScienceDaily. ScienceDaily, 18 September 2019.

Growth Hormone: What You Need To Know

Article found here: Growth Hormone: What You Need To Know.

Barceló P, Nicolau C, Gamundí A, et al. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxid Med Cell Longev. 2016 PMC6165162

Boguszewski CL. Update on GH therapy in adults [version 1; referees: 3 approved]. F1000Research. 2017 doi: 10.12688/f1000research.12057.1

Bottaro M, Martins B, Gentil P, Wagner D. Effects of rest duration between sets of resistance training on acute hormonal responses in trained women. J Sci Med Sport. 2009;12(1):73-78

Clemmons DR , Underwood LE. Nutritional regulation of IGF-I and IGF binding proteins. Annu Rev Nutr 1991;11:393–412

Coiro V, Vescovi PP. Alcoholism abolishes the effects of melatonin on growth hormone secretion in humans. Neuropeptides. 1998;32(3):211-214

Gjedsted J, Gormsen LC, Nielsen S, et al. Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue. Acta Physiol (Oxf). 2007;191:205–216

Hansen AP. Abnormal serum growth hormone response to exercise in maturity-onset diabetics. Diabetes 1973;22:619–628

Hartman ML , Faria AC , Vance ML , Johnson ML , Thorner MO , Veldhuis JD. Temporal structure of in vivo growth hormone secretory events in humans. Am J Physiol 1991;260:E101–E110

Ho KY , Veldhuis JD , Johnson ML , Furlanetto R , Evans WS , Alberti KG , Thorner MO. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 1988;81:968–975

Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrine Metab. 1991;73(5):1081-1088

Irving BA, Weltman JY, Patrie JT, et al. Effects of Exercise Training Intensity on Nocturnal Growth Hormone Secretion in Obese Adults with Metabolic Syndrome. J Clin Endocrine Metab. 2009;94(6):1979-1986

Jørgensen JO, Pedersen SA, Lauberg P, et al. Effects of Growth Hormone Therapy on Thyroid Function of Growth Hormone-Deficient Adults with and without Concomitant Thyroxine-Substituted Central Hypothyroidism. J Clin Endo Metab. 1989;69(6):1127-1132

Kireev RA, Vara E, Tresguerres JAF. Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats. 2013;14(4):431-442

Matsuo H, Iwamoto A, Otsuka T, et al. Effect of time of L-ornithine administration on the diurnal rhythms of plasma growth hormone, melatonin, and corticosterone levels in mice. Chronobiol Int. 2015;32(2):225-34

Meinhardt UJ, Ho KKY. Modulation of growth hormone action by sex steroids. 2006;65:412-422

Moller N, Jorgensen JO, Schmitz O, Moller J, et al. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol 1990;258:E86–E91

Møller N, Jørgensen JOL. Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects. Endo Rev. 2009;30(2):152-177

Müller E, Locatelli V, Cecchi D. Neuroendocrine Control of Growth Hormone Secretion. Physio Rev 1999;79:511-607

Norrelund H, Djurhuus C, Jorgensen JO, et al. Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients. Am J Physiol Endocrinol Metab 2003;285:E737–E743

Norrelund H, Moller N, Nair KS, et al. Continuation of growth hormone (GH) substitution during fasting in GH-deficient patients decreases urea excretion and conserves protein synthesis. J Clin Endocrinol Metab 2001;86:3120–3129

Parker DC, Sassin JF, Mace JW, Gotlin RW, Rossman LG. Human growth hormone release during sleep: electroencephalographic correlation. J Clin Endocrinol Metab 1969;29:871–874

Paulsen SK, Pedersen SB, Jorgensen JO, et al. Growth hormone (GH) substitution in GH-deficient patients inhibits 11?-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue. J Clin Endocrinol Metab 2006;91:1093–1098

Redman LM, Veldhuis JD, Rood J, et al. The effect of caloric restriction interventions on growth hormone secretion in non-obese men and women. Aging Cell. 2010;9(1):32-39

Roth J , Glick SM , Yalow RS , Berson SA. Secretion of human growth hormone: physiologic and experimental modification. Metabolism 1963;12:577–579

Rudnitskaya EA, Maksimova KY, Muraleva NA, et al. Beneficial effects of melatonin in a rat model of sporadic Alzheimer’s disease. Biogerontology. 2015;16(3):303-316

Valcavi R, Zini M, Maestroni GJ, et al. Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone. Clin Endocrinol. 1993;39(2):193-199

Veldhuis JD, Iranmanesh A, Ho KK, et al. Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72:51–59

Welbourne T. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr. 1995;61:1058-61

Wolthers T, Groftne T, Moller N, et al. Calorigenic effects of growth hormone: the role of thyroid hormones. J Clin Endocrinol Metab. 1996;81:1416–1419

Health Benefits of Probiotics: Your Guide

Article found here: Health Benefits of Probiotics: Your Guide.

Angelakis E, Armougom F,M.Million, Raoult D. The relationship between gut microbiota and weight gain in humans. Future Microbiol. 2012;7:91-109

Barrett E, Ross RP, O’Toole PW, et al. Gamma-amino butyric acid production by culturable bacteria from the human intestine. J Appl Microbiol. 2012;113(2):411-417.

Bazanella M, Maier TV, Clavel T, et al. Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome. Am J Clin Nutr. 2017;106:1274-1286.

Capurso L. Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol. 2019;53:S1-S41.

Clapp M, Aurora N, Herrera L, et al. Gut microbiota’s effect on mental health: The gut-brain axis. Clin Pract. 2017;7(4):987.

Cox AJ, Pyne DB, Saunders PU, Fricker PA. Oral administration of the probiotic Lactobacillus fermented VRI-003 and mucosal immunity in endurance athletes. Br J Sports Med. 2010;44:222-226.

Daliri E, Byong L, Deog O. Current Perspectives on Antihypertensive Probiotics. Probio Antimicro Prot. 2017;9:91-101.

Deans E. Microbiome and mental health in the modern environment. J Physiol Anthropol. 2016;36(1):1.

Engelbrektson AL, Korzenik JR, Sanders ME, et al. Analysis of treatment effects on the microbial ecology of the human intestine. FEMS Microbiol Ecol. 2006;57(2):239-250.

Food and Agriculture Organization of the United Nations/World Health Organization. Report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including milk powder milk with live lactic acid bacteria. FAO/WHO. 2001.

Geovana L, Resende AS, West NP, Lancha AH. Probiotics and sports: A new magic bullet? Nutrition. 2019;60:152-160.

Gerasimov SV, Ivantsiv VA, Bobryk LM, et al. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. 2016;70(4):463-469.

Gerasimov SV, Vasjuta VV, Myhovych OO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dematol. 2010;11(5):351-361.

Hesla HM, Stenius F, Jägerlund L, et al. Impact of lifestyle on the gut microbiota of healthy infants and their mothers – the ALADDIN birth cohort. FEMS Microbiol Ecol. 2014;90:791-801.

Jungersen M, Wind A, Johansen E, et al. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12. Microorganisms. 2014;2(2):92-110.

Kumar M, Dhaka P, Vijay D, et al. Antimicrobial effects of Lactobacillus plantarum and Lactobacillus acidophilus against multidrug-resistant enteroaggregatvie Escherichia coli. Int J Antimicrobial Agents. 2016;48:265-270.

Lamprecht M, Frauwallner A. Exercise, intestinal wall barrier dysfunction and probiotic supplementation. Med Sport Sci. 2012;59:47-56.

Lew LC, Hor YY, Yusoff NAA. Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study. Clin Nutr. 2018; doi: 10.1016/j.clnu.2018.09.010.

Leyer GJ, Li S, Mubasher ME, et al. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172-179.

Li Q, Zhou JM. The microbiota-gut-brain axis and its potential role in autism spectrum disorder. Neuroscience. 2016;324:131-139.

Margo DO, de Oliveira LM, Bernasconi I, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactic HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J 2014; doi: 10.1186/1475-2891-13-75.

Michalickova D, Minic R, Dikic N, et al. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. Appl Physiol Nutr Metab. 2016;41:782-879.

Minami J, Iwabuchi N, Tanaka M, et al. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Biosci Microbio Food Health. 2018;37(3):67-75.

Mohajeri MH, La Fata G, Steinert RE, Weber P. Relationship between the gut and brain function. Nutr Rev. 2018;76(7):481-496.

Montes RG, Bayless TM, Saavedra JM, Perman JA. Effects of milks inoculated with Lactobacillus acidophilus or a yogurt starter culture in lactose-maldigesting children. J Dairy Sci. 1995;78(8):1657-1664.

Naidu AS, Bidlack WR, Clemens RA. Probiotic spectra of lactic acid bacteria (lab). Crit Rev Food Sci Nutr. 1999;39(1):13-126.

Nagala M, Routray M. Clinical case study —multispecies probiotic supplement minimizes symptoms of irritable Bowel Syndrome. US Gastro Hepato Rev. 2011;7:36-37.

Naseribafrouei A, Hestad K, Avershina E, et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil. 2014;26(8):1155-1162.

Oak SJ, Jha R. The effects of probiotics in lactose intolerance: a systematic review. Crit Rev Food Sci Nutr. 2018:1-9.

Pavlović N, Stankov K, Milov M. Probiotics–interactions with bile acids and impact on cholesterol metabolism. App Biochem Biotechnol 2012;168:1880-1895.

Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019;10(Suppl 1):549-566.

Rajkumar H, Mahmood N, Kumar M, et al. Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: a randomized, controlled trial. Mediators Inflamm. 2014;348959.

Rather IA, Bajpai VK, Kumar S, et al. Probiotics and Atopic Dermatitis: An Overview. Front Microbiol. 2016;7:507.

Ringerl-Kulka T, Palsson OS, Maier D, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactic Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45(6):518-525.

Roberts JD, Suckling CA, Peedle GY, et al. An exploratory investigation of endotoxin levels in novice long distance triathletes, and the effects of a mult-strain probiotic/prebiotic, antioxidant intervention. Nutrients. 2016;8 pie:E733.

Sánchez B, Delgado S, Blanco-Míguez A, Lourenço A, et al. Probiotics, gut microbiota, and their influence on health and disease. Mol Nutr Food Res. 2017;1600240.

Sharafedtinov KK, Plotnikova OA, Alexeeva RI, et al. Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients–a randomized double-blind placebo-controlled pilot study. Nutr 2013;12:138.

Shing CM, Peake JM, Lim CL, et al. Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. Eur J Appl Physiol. 2014;114;93-103.

Stanton C, Ross RP, Fitzgerald GF, Sinderen DV. Fermented functional foods based on probiotics and their biogenic metabolites. Curries Opin Biotechnol. 2005;16(12):198-203.

Steenbergen L, Sellaro R, van Hemert S, et al. A randomized controlled trip to test the effect of multi species probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015;doi:10.1016/j.bbi.2015.04.003.

Suda RM, Bhonagiri S. Efficacy of Bacillus coagulans in strain unique is-2 in the treatment of patients with acute diarrhea. Int J Probio Prebio. 2012;7(1):33-37.

Szajewska H, Canani RB, Guarino A, et al. Probiotics for the prevention of antibiotic-associated diarrhea in children. J Pediatr Gastroenterol Nutr. 2016;62:495-506.

Upadrasta A, Madempudi RS. Probiotics and blood pressure: current insights. Int Blood Press Control. 2016;9:33-42.

Upadrasta A, Stanton C, Hill C, et al. Improving the stress tolerance of probiotic cultures: Recent trends and future directions. Springer US. 2011:395-438.

Vandenbergh PA, Lactic acid bacteria, their metabolic products and interference with microbial growth. FEMS Microbiology Reviews. 1993;12(1-3):221-237.

West CE, Jenmalm MC, Prescott SL. The gut microbiota and its role in the development of allergic disease: a wider perspective. Clin Exp Allergy. 2015;45:43-53.

West NP, Pyne DB, Cripps AW, et al. Lactobacillus fermentum (PCC®) supplementation and gastrointestinal and respiratory illness symptoms: A randomized control trial in athletes. Nutrition J 2011;10:30.

Zhang GQ, Hu HJ, Liu CY, et al. Probiotics for prevention of atophy and food hypersensitivity in early childhood: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore). 2016;95:e2562.

Hemp, Essential Oils, and the Endocannabinoid System: Your Guide

Article found here: Hemp, Essential Oils, and the Endocannabinoid System: Your Guide.

Alger BE. Getting High on the Endocannabinoid System. Cerebrum. 2013;14

Allen KL, Waldvogel HJ, Glass M, Faull RLM. Cannabinoid (CB1), GABAA and GABAB receptor subunit changes in the globus pallidus in Huntington’s disease. Journal of Chemical Neuroanatomy 2009;37:266–281.

Ancient Origins. Cannabis: A Journey through the Ages. Accessed May 14 2018

Borgelt L, Franson K, Nussbaum A, Wang G. The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy. 2013;33(2):195-209

Breus MJ. The Ultimate Guide to CBD and Sleep. Huffington Post. Sept 2017. Acquired May 17 2018.

Chen A. Some of the Parts: Is Marijuana’s “Entourage Effect” Scientifically Valid? Scientific American. April 20 2017. Acquired May 17 2018

Chouker A, Kaufmann I, Kreth S, et al. Motion sickness, stress and the endocannabinoid system. PLoS ONE 2010;5

Delkic M. Legal Marijuana Lights Up Sales For McDonald’s and Taco Bell. Newsweek. Sept 2017 Acquired May 16 2018.

De Meijer E, Hammond K. The inheritance of chemical phenotype in Cannabis sativa L.(II): cannabigerol predominant plants. Euphytica 2005;145(1-2):189-198.

Di Filippo M, Pini LA, Pelliccioli GP, et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. Journal of Neurology Neurosurgery and Psychiatry. 2008;79:1224–1229.

Di Marzo V. ‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance. Biochimica et Biophysica Acta – Lipids and Lipid Metabolism. 1998;1392:153–175.

Dyall SC. Interplay Between n?3 and n?6 Long?Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair. Lipids. 2017;52:885-900

Fride E. The endocannabinoid-CB receptor system: Importance for development and in pediatric disease. Neuroendocrinology Letters. 2004;25:24–30.

Gerard N, Pieters G, Goffin K, (2011) Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa. Biological Psychiatry 2011;70:777–784.

Gertsch J, Leonti M, Raduner S, et al. Beta-caryophyllene is a dietary cannabinoid. Proc Natl Acad Sci 2008;105(26):9099-9104.

Gertsch J, Roger G, Vincenzo D. Phytocannabinoids beyond the cannabis plant – do they exist? Br J Pharmacol 2010;160(3):523-529.

Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, et al. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology 2004;29:2108–2114

Head K. Endocannabinoid System 101. Thorne website. Retrieved May 15, 2018.

Hill MN, Gorzalka BB. Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression? Behav Pharmacol. 2005;16:333–352.

Holman EA, Guijarro A, Lim J, Piomelli D. Effects of acute stress on cardiac endocannnabinoids, lipogenesis, and inflammation in rats. Psychosom Med. 2014;76(1):20-28

Interventions that Upregulate the Endocannabinoid System Mead A. The legal status of cannabis (marijuana) and cannabidiol (CBD) under U.S. law. Epilepsy Behav. 2017;70(Pt B):149-153

Izzo A, Capasso R, Aviello G, et al. Inhibitory effect of cannabichromene, a major non?psychotropic cannabinoid extracted from Cannabis sativa, on inflammation?induced hypermotility in mice. Br J Pharmacol 2012;166(4):1444-1460.

Johnson R. Hemp as an agricultural commodity. Library of Congress, Washington DC, Congressional Research Service, 2014

Klauke A, Racz I, Pradier B, et al. The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol 2014;24(4):608-620.

Leonti M, Casu L, Raduner S, et al. Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol 2010;79(12):1815-1826.

Life Science. 5 Differences Between Hemp and Marijuana. Sep 2014. Accessed March 27, 2018

Lutz B, Marsicano G, Malonado R, Hillard CJ. The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci. 2015;16(12):705-718

McPartland JM, Giuffrida A, King J, et al. Cannabimimetic effects of osteopathic manipulative treatment. Journal of the American Osteopathic Association 2005;105:283–291

McPartland JM, Guy GW, Di Marzo V. Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical. PLoS One. 2014;9(3): e89566

Oláh A, Markovics A, Szabó?Papp J, et al. Differential effectiveness of selected non?psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrheic skin and acne treatment. Exp Dermatol 2016;25(9):701-707.

Oregon State University: Micronutrient Information Center. Indole-3 Carbinol. Linus Pauling Institute Retrieved May 16 2018

Pisani V, Moschella V, Bari M, et al. Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson’s disease patients. Movement Disorders 2010;25:920–924.

Raduner S, Majewska A, Chen J, et al. Alkylamides from Echinacea are a new class of cannabinomimetics Cannabinoid type 2 receptor-dependent and-independent immunomodulatory effects. J Biol Chem 2006;281(20):14192-14206.

Russo EB. Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinol Lett. 2004;25: 31–39.

Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344-1364

Sarchielli P, Pini LA, Coppola F, et al. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. Neuropsychopharmacology. 200732:1384–1390.

Shinjyo N, Di Marzo V. The effect of cannabichromene on adult neural stem/progenitor cells. Neurochem Int 2013;63(5):432-437.

Tang J, Dunlop R, Rowe A, et al. Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. Phytother Res 2011;25(3):417-423.

University of Illinois. Omega-3 Fatty Acids Fight Inflammation via Cannabinoids. Neuroscience News. Retrieved May 15 2018.

Van Laere K, Casteels C, Dhollander I, et al. Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. Journal of Nuclear Medicine 2010;51:1413–1417.

Wirth P, Watson E, ElSohly M, et al. Anti-inflammatory properties of cannabichromene. Life Sci 1980;26(23):1991-1995.

Wong BS, Camilleri M, Eckert D, Carlson P, Ryks M, et al. Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea. Neurogastroenterology and Motility 2012;24.

Yin H, Chu A, Li W, et al. Lipid G protein-coupled receptor ligand identification using ?-arrestin PathHunter™ assay. J Biol Chem 2009;284(18):12328-12338.

High Protein Diets: What You Need to Know

Article found here: High Protein Diets: What You Need to Know.

Aller EE, Larsen TM, Claus H, Lindroos AK, Kafatos A, et al. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results. Int J Obes (Lond). 2014;38(12):1511-7

Bray GA, Smith SR, de Jonge L, Xie H, Rood J, et al. Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating. JAMA. 2012;307(1):47-55

Cao JJ, Johnson LK, Hunt JR. A Diet High in Meat Protein and Potential Renal Acid Load Increases Fractional Calcium Absorption and Urinary Calcium Excretion without Affecting Markers of Bone Resorption or Formation in Postmenopausal Women. J Nutr. 2011;141:391-397

Clifton P. Effects of a high protein diet on body weight and comorbidities associated with obesity. Br J Nutr. 2012;108(Suppl 2):S122-9

Clifton PM, Condo D, Keogh JB. Long term weight maintenance after advice to consume low carbohydrate, higher protein diets—a systematic review and meta analysis. Nutr Metab Cadriovasc Dis. 2014;24(3):224-35

Cuenca-Sánchez M, Savas-Carrillo D, Orenes-Piñero E. Controversies Surrounding High-Protein Diet Intake: Satiating Effect and Kidney and Bone Health. Adv Nutr. 2015;6(3):260-266. Obesity. 2013;21(9):1774-1781

de Luis DA, Izaola O, Aller R, de la Fuente B, Bachiller R, Romero E. Effects of a high-protein/low-carbohydrate versus a hypocaloric diet on adipocytokine levels and insulin in obese patients along 9 months. J Diabetes Complications. 2015;29(7):950-4.

Deutz NE, Wolfe RR. Is there a maximal anabolic response to protein intake with a meal? Clin Nutr. 2013;32:309-313

Farnswoth E, Luscombe ND, Noakes M, Wittert G, Argyiou E, Clifton PM. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin Nutr. 2003;78(1):31-9

Gosby AK, Conigrave AD, Raubenheimer D, Simpson SJ. Obes Rev. 2014;15(3):183-91

Grave RD, Calugi S, Gravasso I, Ghoch ME, Marchesini G. A randomized trial of energy-restricted high-protein versus high-carbohydrate, low-fat diet in morbid obesity. Obesity. 2013;21(9):1774-81.

Halton TL, Hu FB. The effects o high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr. 2004;23(5):373-85

Helms ER, Zinn C, Rowlands DS, Naidoo R, Cronin J. Hight-protein, low-fat, short-term diet results in less stress and fatigue than moderate-protein moderate-fat diet during weight loss in male weightlifters: a pilot study. Int J Sport Nutr Exerc Metab. 2015;25(2)163-70.

Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for energy, carbohydrates, fiber, fat, protein and amino acids (macronutrients). Washington (DC): National Academies Press, 2002.

Johnston AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Am J Clin Nutr. 2008;87(1):44-55

Journel M, Chaumontet C, Darcel N, Fromentin G, Tomé D. Brain Responses to High-Protein Diets. Adv Nutr. 2012;3(3):322-329

Keller U. Dietary proteins in obesity and in diabetes. Int J Vitam Nutr Res. 2011;81(2-3):125-33

Kerstetter JE, Caseria DM, Mitnick ME, Ellison AF, Gay LF, Liskov TA, Carpenter TO, Insogna KL.Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. Am J Clin Nutr. 1997;66:1188–96.

Kerstetter JE, O’Brien KO, Caseria DM, Wall DE, Insogna KL. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab. 2005;90:26–31.

Krieger JW, Sitten HS, Daniels MJ, Langkamp-Henken B. Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression. Am J Clin Nutr. 2006;83(2):260-274

Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, et al. Diets with High or Low Protein Content and Glycemic Index for Weight-Loss Maintenance. N Engl J Med. 2010;363(22):2102-2113

Leidy HJ, Lepping RJ, Savage CR, Harris CT. Neural Responses to Visual Food Stimuli After a Normal vs. Higher Protein Breakfast in Breakfast-Skipping Teens: A Pilot fMRI Study. Obesity. 2011;19(10):2019-2025

McAuley KA, Hopkins CM, Smith KJ, McLay RT, Williams SM, Taylor RW, Mann JI. Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia. 2005;48(1):8-16

Munger RG, Cerhan JR, Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr. 1999;69(1):147-52

O’Connell MB, Madden DM, Murray AM, Heaney RP, Kerzner LJ. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778–81.

Phillips SM. Dietary protein for athletes: from requirements to metabolic advantage. App Physiol Nutr Metab. 2006;31(6):647-54

Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985;313:70–3.

Soenen S, Westerterp-Plantenga MS. Changes in body fat percentage during body weight stable conditions of increased daily protein intake vs. control. Physical Behav. 2010;101(5):635-638

Teunissen-Beekman KFM, Dopheide J, Geleijnse JM, Bakker SJL, Brink EJ, et al. Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial. Am J Clin Nutr. 2012;95:966-71

Westerterp KR. Diet induced thermogenesis. Nutr Metab (Lond). 2004;1(5) doi:  10.1186/1743-7075-1-5

Westerterp-Plantenga MS, Nieuwenhuizen A, Tomé D, Soenen S, Westerterp KR. Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr. 2009;29:21-41

Wycherley TP, Moran LJ, Clifton PM, Noakes M, Brinkworth GD. Am J Clin Nutr. 2012;96(6):1281-1298

Wycherley TP, Noakes M, Clifton PM, Cleanthous X, Keogh JB, Brinkworth GD. A High-Protein Diet With Resistance Exercise Training Improves Weight Loss and Body Composition in Overweight and Obese Patients With Type 2 Diabetes. Diabetes Care. 2010;33:969-976

High-Quality Multivitamin: What To Look For

Article found here: High-Quality Multivitamin: What To Look For.

Bailey RL. The Epidemiology of Global Micronutrient Deficiencies. Ann Nutr Metab. 2015;66(suppl 2):22-33.

Committee on Micronutrient Deficiencies, Board on International Health, Food and Nutrition Board; Howson CP, Kennedy ET, Horwitz A: Prevention of Micronutrient Deficiencies: Tools for Policymakers and Public Health Workers. Washington, National Academy Press, 1998.

Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005;19(1):59–65.

Earth Talk. Dirt Poor: Have Fruits and Vegetables Become Less Nutritious? Scientific American. 2011. Retrieved Aug 6 2017

Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod. 2007;13(2):163–74.

Food and Nutrition Board: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, National Academy Press, 2001

National Institutes of Health. Folate: Dietary Supplement Fact Sheet. Retrieved Aug 9 2017.

Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012;3(2):158-65.

West KP, Stewart CP, Caballero B, Black RE. Nutrition; in Merson MH, Black RE, Mills AJ (eds): Global Health: Diseases, Programs, Systems, and Policies, ed 3. Burlington, Jones and Bartlett Learning, 2012, pp 271–304.


How to Use Critical Thinking with Essential Oils Cynics

Article found here: How to Use Critical Thinking with Essential Oils Cynics.

Ali B, Al-Wabel NA, Shams S, et al. Essential oils used in aromatherapy: A systemic review. Asian Pac J Trop Biomed. 2015;5(8):601-611

Henley D, Lipson N, Korach K, Bloch C. Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils. N Engl J Med. 2007;356:479-85

Khine H, Weiss D, Graber N, Hoffman RS, Esteban-Cruciani N, Avner JR. A cluster of children with seizures caused by camphor poisoning. Pediatrics. 2009; 123:1269-2097.

Landelle C, Francony G, Sam-Lai NF, et al. Poisoning by lavindin extract in a 18-month-old-boy. Clin Toxicol (Phila) 2008;46(4):279-81

Poison Control. Kitchen Surprises and Cautions. Retrieved July 19 2017.

U.S. Food & Drug Administration. What does FDA regulate? Retrieved July 23 2017.

Wolf A. Essential Oil Poisoning. Clin Toxicol. 1999;37(6):721-727

Intermittent Fasting and Breakfast: What You Need To Know

Article found here: Intermittent Fasting and Breakfast: What You Need To Know.

Arnason TG, Bowen MW, Mansell KD. Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study. World J Diabetes. 2017;8(4):154-164

Betts JA, Richardson JD, Chowdhury EA, Homan GD, Tsintzas K, Thompason D. The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults. Am J Clin Nutr. 2014;100:539-547

Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Varady KA. Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans. Obesity. 2013;21:1370–1379. doi: 10.1002/oby.20353. 

Bock KD, Derave W, Eijnde BO, Hesselink MK, Koninckx E, at al. Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake. J App Physiol. 2008;104(4):1045-1055

Bouhlel E, Salhi Z Bouhle H, Mdella S, Amamou A, et al. Effect of Ramadan fasting on fuel oxidation during exercise in trained male rugby players. Diabetes Metab. 2006;32(6):617-24

Bouhlel E, Zaouali M, Miled A, Tabka Z, Bigard X, Shephard R. Ramadan fasting and the GH/IGF-1 axis of trained men during submaximal exercise. Ann Nutr Metab. 2008;52(4):261-266

Chaouachi A, Leiper JB, Chtourou H, Aziz AR, Chamari K. The effects of Ramadan intermittent fasting on athletic performance: recommendations for the maintenance of physical fitness. J Sports Sci. 2012;30:S53-73

Chiofalo B, Laganà AS, Palmara V, Granes R, Corrado G, et al. Fasting as possible complementary approach for polycystic ovary syndrome: Hope or hype? Med Hypotheses 2017;105:1-3 doi: 10.1016/j.mehy.2017.06.013.

Fann DY, Santo T, Manzanero S, Widiapradja A, Cheng YL, et al. Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp Neurol. 2014;257:114-119

Gnanou JV, Caszo BA, Khalil KM, Abdullah AL, Knight VF, Bidin MZ. Effects of Ramadan fasting on glucose homeostasis and adiponectin levels in healthy adult males. J Diabetes Metab Disord. 2015;14:55 doi:  10.1186/s40200-015-0183-9

Gur EB, Turan GA, Ince O, Karadeniz M, Tatar S, et al. Effect of Ramadan fasting on metabolic markers, dietary intake and abdominal fat distribution in pregnancy. Hippokratia. 2015;19(4):298-303

Klempel MC, Kroeger CM, Bhutani S, Trepanowski JF, Varady KA. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutr J. 2012;11:98. doi: 10.1186/1475-2891-11-98.

Klempel MC, Kroeger CM, Varady KA. Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans. Eur J Clin Nutr. 2013;67:783–785. doi: 10.1038/ejcn.2013.83.

Manzanero S, Erion JR, Santro T, Steyn FJ, Chen C, Arumugam TV, et al. Intermittent fasting attenuates increases in neurogenesis after ischemia and repercussion and improves recovery. J Cereb Blood Flow Metab. 2014;34(5):897-905

Moro T, Tinsley G, Bianco A, Marcolin G, Pacelli QF, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Trans Med. 2016;13:290 doi:  10.1186/s12967-016-1044-0

Proeyen KV, Szlufcik K, Nielens H, Ramaekers M, Hespel P. Beneficial metabolic adaptations due to endurance exercise training in the fasted state. J Appl Physiol. 1985;110(1):236-245

Siegelbaum D. What does America have for breakfast? BBC News Online. August 2014. Retrieved October 9 2017.

Stannard SR. Ramadan and Its Effect on Fuel Selection during Exercise and Following Exercise Training. Asian J Sports Med. 2011;2(3):127-133

Stannard SR, Thompson MW . The effect of participation in Ramadan on substrate selection during submaximal cycling exercise. J Sci Med Sport. 2008;11(5):510-7.

Talib RA, Canguven O, Al-Rumaihi K, Al Ansari A, Alani M. The effect of fasting on erectile function and sexual desire on men in the month of Ramadan. Urol J. 2015;12(2):2099-102

Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev. 2015;73:661–674. doi: 10.1093/nutrit/nuv041.

Varady KA, Bhutani S, Church EC, Klempel MC. Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr. 2009;90:1138–1143. doi: 10.3945/ajcn.2009.28380.

Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr. 2007;86:7–13.

Varady KA, Bhutani S, Klempel MC, Lamarche B. Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults. Br J Nutr. 2011;105:580–583. doi: 10.1017/S0007114510003788.

Wegman MP, Guo MH, Bennion DM, Shankar MN, Chrzanowski SM, et al. Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and Metabolism. Rejuvenation Res. 2015;18(2):162-172

Zarrouk N, Hammouda O, Latiri I, Adala H, Bouhlel E, et al. Ramadan fasting does not adversely affect neuromuscular performances and reaction times in trained karate athletes. J Int Soc Sports Nutr. 2016;13:18 doi:  10.1186/s12970-016-0130-2

Zuo L, He F, Tinsley GM, Pannell BK, Ward E, Arciero PJ. Comparison of High-Protein, Intermittent Fasting Low-Calorie Diet and Heart Health Diet for Vascular Health of the Obese. Front Physiol. 2016;7:350 doi:  10.3389/fphys.2016.00350

Irritable Male Syndrome, Andropause, and Reclaiming Your Manhood

Article found here: Irritable Male Syndrome, Andropause, and Reclaiming Your Manhood.

Bain J. Andropause. Testosterone replacement therapy for aging men. Can Fam Physician. 2001;47:91–97.

Cherrier MM, Asthana S, Plymate S, et al. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology. 2001;57:80–88.

Cherrier MM, Matsumoto AM, Amory JK, et al. Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology. 2005;64:2063–2068.

Chu LW, Tam S, Lee PW, et al. Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men. Clin Endocrinol (Oxf) 2008;68:589–598.

Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, et al. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA. 2008;299:39–52.

Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab. 2002;87(2):589–598.

Hassan J, Barkin J. Testosterone deficiency syndrome: benefits, risks, and realities associated with testosterone replacement therapy. Can J Urol. 2016;23(Suppl 1):20-30

Harrison J. ‘Talking about my generation’: a state-of-the-art review of health information for men in the andropause. Health Info Libr J. 2011;28:161-170.

Hyde Z, Norman PE, Flicker L, et al. Low free testosterone predicts mortality from cardiovascular disease but not other causes: the Health in Men Study. J Clin Endocrinol Metab. 2008;97:179–189.

Jakiel G, Makara-Studzi?ska M, Ciebiera M, S?abuszewska-Jó?waiak A. Andropause – state of the art 2015 and review of selected aspects. Prz Menoppauzalny. 2015;14(1):1-6 DOI: 10.5114/pm.2015.49998

Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes Care. 2007;30(4):911–917.

O’Donnell AB, Travison TG, Harris SS, et al. Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2006;91:425-431.

Rabijewski M. Osteoporoza u m??czyzn. Prz Urol. 2006;35:43-45.

Rabijewski M, Papierska L, Kuczerowski R, Piatkiewicz. Hormonal determinants of the severity of andropausal and depressive symptoms in middle-aged and elderly men with prediabetes. Clin Inter Aging. 2015;10:1381-1391

Riley B. Autoimmune diseases and reproductive aging. Clin Immunol. 2013;149(2):251-264

Srinivas-Shankar U, Roberts SA, Connolly MJ, et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2010;95:639–650.

Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry. 1998;155:1310-1318

Storer TW, Woodhouse L, Magliano L, et al. Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men. J Am Geriatr Soc. 2008;56:1991–1999.

Tkaczyszyn M, Nega K, ?opusza?ska M, et al. Andropausal syndrome in men with systolic heart failure. Pol Arch Med Wew. 2013;123(4):156–169.

Wu FC, Tajar A, Beynon JM, et al. EMAS Group. Identification of lateonset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010;363:123-135.

Wylie K, Froggatt N. Late onset hypogonadism, sexuality and fertility. Hum Fertil (Camb).2010;13:126-133.

Is Hydrogen-Rich Water Good For You?

Article found here: Is Hydrogen-Rich Water Good For You?

Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilot Study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research. 2012;2:12

Dole M, Wilson FR, Fife WP. Hyperbaric hydrogen therapy: a possible treatment for cancer. Science. 1975;190:152-154

Ito M, Ibi T, Sahashi K, Ichihara M, Ohno K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research. 2011;1:24

Kajiyama S, Hasegawa G, Asano M, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research. 2008;28(3):137–143.

Kang KM, Kang YN, Choi IB et al. Effects of drinking hydrogen-rich water on the quality of life of patients with radiotherapy for liver tumors. Medical Gas Research. 2011;1:11

Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46:140-149

Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology. 2009;34(2):501–508.

Nakayama M, Kabayama S, Nakano H, et al. Biological effects of electrolyzed water in hemodialysis. Nephron. 2009;112(1):C9–C15.

Ohno K, Ito M, Ichihara M, Ito M. Molecular Hydrogen as an Emerging Therpeutic Medical Gas for Neurodegenerative and Other Diseases. Oxidative Medicine and Cellular Longevity. 2012;353152 doi:10.1155/2012/353152

Ono H, Nishijima Y, Adachi N, et al. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research. 2011;1:12

Ostojic SM. Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives. Int J Sports Med. 2014. Doi 10.1055/s-0034-1395509

Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knock-out mice. Biochem Biophys Res Commun. 2008;375:346-350

Song G, et al. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res. 2013;54:1884-1893

Lavender and Tea Tree Essential Oils and Gynecomastia (Boys with Boobs)

Article found here: Lavender and Tea Tree Essential Oils and Gynecomastia (Boys with Boobs).

Diaz A, Luque L, Badar Z, Kornic S, Danon M. Prepubertal gynecomastia and chronic lavender exposure: report of three cases. J Pediatr Endocrine Metab. 2016;29(1):103-7

Lemaine V, Cayci C, Petty P,. Gynecomastia in Adolescent Males. Semin Plast Sorg 2013;27(1):56-61

Lopez-Rodriguez JA, Duelo Marcos M. Unilateral gynecomastia in young male due to tea tree oil. An Pediatric (Barc). 2014;81(6):e18-19

Mandras N, et al. BMC Complement Altern Med 2016;16(1):330

Zhao Y, Chen R, Wang Y, et al. In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer. Integr Cancer Ther 2017;16(2)251-226

Limonene: Health Benefits Of An Essential Oils Constituent

Article found here: Limonene: Health Benefits Of An Essential Oils Constituent

Al-Harrasi A, Al-Saidi S. Phytochemical Analysis of the Essential Oil from Botanically Certified Oleogum Resin of Boswellia sacra (Omani Luban). Molecules. 2008;13:2181-2189.

Berlicche L, Ciociaro A, Russo R, et al. Toxic profile of bergamot essential oil on survival and proliferation of SH-SY5Y neuroblastoma cells. Food and Chem Toxicol. 2011;49(11):2780-2792.

Campêlo LML, de Almeida AA, de Freitas RLM, et al. Antioxidant and Antinociceptive Effects of Citrus limon Essential Oil in Mice. J Biomed Biotech. 2011;ID 678673.

de Rapper S, Kamatou G, Viljoen A, van Vuuren S. The In Vitro Antimicrobial Activity of Lavandula angustifolia Essential Oil in Combination with Other Aroma-Therapeutic Oils. Evid-Based Compl Alt Med. 2013;ID 852049  

Filipsson AF, Bard J, Karlsson S. Limonene, fifth ed., World Health Organization. 1998, p. 32.

Haze S, Sakai K, Gozu Y. Effects of Fragrance Inhalation on Sympathetic Activity in Normal Adults. Jpn J Pharmacol. 2001;90:247-253.

Hirota R, Roger NN, Nakamura H, et al. Anti-inflammatory effects of limonene from yuzu (citrus Junos Tanaka) essential oil on eosinophils. J Food Sci. 2010;H87-H92.

International Programme On Chemical Safety. Limonene: Concise International Chemical Assessment Document No. 5. Retrieved November 21 2018.

Paul RG, Bailey AJ. The effect of advanced glycation end-product formation upon cell-matrix interactions. Int J Biochem Cell Biol. 1999;31(6):653-660.

Rehman MU, Tahir M, Khan AQ, et al. D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFkB in kidneys of Wistar rats. Exp Biol Med. 2014;239(4):456-476.

Roberto D. Micucci P, Sebastian T, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H202 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010;106:38-44.

Rufino AT, Ribeiro M, Sousa C, et al. Evaluation of the anti-inflammatory, anti-catabolic, and pro-anabolic effects of E-caryophyllene, myrcene, and limonene in a cell model of osteoarthritis. Our J Pharmacol. 2015;750:151-150.

Russo R, Ciociaro A, Berliocchi L, et al. Implication of limonene and lineally acetate in cytotoxicity induced by bergamot essential oil in human neuroblastoma cells. Fitoterapia. 2013;89:48-57

Schmidt L, Göen T. R-Limonene metabolism in humans and metabolite kinetics after oral administration. Arch Toxicol. 2017;91:1175-1185.

Theis N, Verdau M, The evolution of function in plant secondary metabolites. Int J Plant Sci. 2003;164(S3):S93-S102.

Vieira AJ, Beserra FP, Souza MC, et al. Limonene: Aroma of innovation in health and disease. Chem Bio Inter. 2018;283:97-106.

Wilson MJ, Lindgren BR, Sinha AA. The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. Exp Mol Pathol. 2008;85(2):83-89. 

Low-Carb vs Low-Fat vs High-Protein: Which Diet Is Best?

Article found here: 

Aragon AA, Schoenfeld BJ, Wildman R, et al. International Society of Sports Nutrition position stand: diets and body composition. J Int Soc Sport Nutr. 2017;14.

Hall K, Guo J. Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology. Gastroenterology. 2017;152(7):1718-27.

Hooper LAA, Bunn D, Brown T, Summerbell CD, Skeaff CM. Effects of total fat intake on body weight. Cochrane Database Syst Rev. 2015;7(8):CD011834.

Makris A, Foster G. Dietary approaches to the treatment of obesity. Psychiatr Clin North Am. 2011;34(4):813–27.

Manore M. Exercise and the institute of medicine recommendations for nutrition. Curr Sports Med Rep. 2005;4(4):193–8.

Soenen S, Bonomi A, Lemmens S, Scholte J, Thijssen M, van Berkum F, et al. Relatively high-protein or ‘low-carb’ energy-restricted diets for body weight loss and body weight maintenance? Physiol Behav. 2012;107(3):374–80.

Weigle D, Breen P, Matthys C, Callahan H, Meeuws K, Burden V, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr. 2005;82(1):41–8.

Low Testosterone: What You Need to Know

Article found here: Low Testosterone: What You Need to Know.

Adaikan PG, Gauthaman K, Prasad RN, Ng SC. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. Ann Acad Med Singapore. 2000;29(1):22–26

Ahmad MK, Mahdi AA, Sukla KK, et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and antioxidative stress in seminal plasma of infertile males. Fertility and Sterility. 2010;94(3):989-996

Araujo AB, Travison TG, Leder BZ, McKinlay JB. Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men. J Clin Endocrinol Metab. 2008;93:2135–41.

Atlantis E, Fahey P, Martin S, et al. Predictive value of serum testosterone for type 2 diabetes risk in men. BMC Endocrine Disorders. 2016;16:26

Balin J. The many faces of testosterone. Clin Interv Aging. 2007;2(4):567-576

Bao Y, Johansen KL. Diagnosis and treatment of low testosterone among patients with end-stage renal disease. Semin Dial. 2014

Cangemi R, Friedmann AJ, Holloszy JO, Fontana L. Long-term effects of calorie restriction on serum sex-hormone concentrations. Aging Cell. 2010;9(2):236-242

Cha JS, Park JK. The relationship between serum total testosterone and free testosterone levels with serum hemoglobin and hematocrit levels: a study in 1221 men. Aging Male. 2016;19(4):290-214

Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S. Phytopharmacological overview of Tribulus terrestris. Phamacon Rev. 2014;8(15):45-51

Chin KY, Ima-Nirwana S, Wan Ngah WZ. Vitamin D is significantly associated with total testosterone and sex hormone-binding globulin in Malaysian men. Aging Male. 2015;18(3):175-179

Chu S, Qu W, Pang X, Sun B, Huang X. Effect of saponin from Tribulus terrestris on hyperlipidemia. Zhong Yao Cai. 2003;26:341–4. [PubMed: 14535016]

Dandona P, Rosenberg MT. A practical guide to male hypogonadism in the primary care setting. Int J Clin Pract. 2010;64(6):682-696

Dabbs JM, Mohammed S. Male and female salivary testosterone concentrations before and after sexual activity. Physiol Behav. 1992;52(1):195-197

de Souza KZ, Vale FB, Gerber S. Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause. 2016;23(11):1252-1256

Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandah (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Bio Med Res. Int. 2015.

Enter D, Terburg D, Harrweijn A, Spinhoven P, Roelofs K. Single dose testosterone administration alleviates gaze avoidance in women with Social Anxiety Disorder. Psychoneuroendocrinology. 2016;63:26-33

Estley CJ, Amdur RL, Irwig MS. High Rates of Depression and Depressive Symptoms among Men Referred for Borderline Testosterone Levels. J Sex Med. 2015;12(8):1753-60

Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction—an evaluation using primates, rabbit and rat. Phytomedicine 2008;15(1–2):44–54

Ghiciuc CM, Dima-Cozma LC, Bercea RM, et al. Imbalance in the diurnal salivary testosterone/cortisol ratio in men with severe obstructive sleep apnea: an observational study. Braz J Otorhinolaryngol. 2016;82(5):529:535

Goldey KL, van Anders SM. Sexy thoughts: Effects of sexual cognitions on testosterone, cortisol, and arousal in women. Res on Sex Arous. 2011;59(5):754-764

Guay A, Davis SR. Testosterone insufficiency in women: fact or fiction? Excerpt from World Urology 2002. 20:106-110

Gunnels TA, Bloomer RJ. Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements. J Plant Biochem & Physiol. 2:130 doi:10.4172/2329-9029.1000130

Haffner SM, Karhapää P, Mykkänen L, Laakso M. Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 1994;43:212-9

Hassan J, Barkin J. Testosterone deficiency syndrome: benefits, risks, and realities associated with testosterone replacement therapy. Can J Urol. 2016;23(Suppl 1):20-30

Heijboer AC, Oosterwerff M, Schroten NF, et al. Vitamin D supplementation and testosterone concentrations in male human subjects. Clin Endocrinol. 2015;83(1):105-110

Hisasue S. Contemporary perspective and management of testosterone deficiency: Modifiable factors and variable management. Int J Urology. 2015;22:1084-1095

Hsieh CJ, Huang B. Rosuvastatin decreases testosterone levels but not sexual function in men with type 2 diabetes. Diabetes Res Clin Pract. 2016;120:8-88

Kacker R, Conners W, Zade J, Morgentaler A. Bone mineral density and response to treatment in men younger than 50 years with testosterone deficiency and sexual dysfunction or infertility. J Urol. 2014;19(4):1072-1076

Krysiak R, Gilowski W, Okopie?. The effect of testosterone on cardiometabolic risk factors in atorvastatin-treated men with late-onset hypogonadism. Pharmacol Rep. 2016;68(1):196-200

Leão L, Duarte M, Farias ML. Female Androgen Insufficiency and Potential Risks of Therapeutic Replacement. Arg Bras Endocinol Metab. 2005;49:205-216

Lu W, Du N, Liu Y, et al. Low Testosterone Level and Risk of Alzheimer’s Disease in Elderly Men: a Systematic Review and Meta-Analysis. Mol Neurobiol. 2016;53(4):2679-84

Mayo Medical Laboratories. Mayo Clinic. Testosterone, Total, Bioavailable, and Free, Serum.

Michnovicz JJ, Bradlow HL. Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans. J Natl Cancer Inst. 1990;82(11):947-949

Moffat SD, Zonderman AB, Metter EJ, et al. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab. 2002;87:5001–7.

Mulligan T, Frick MF, Zuraw QC, Stemhagen A, McWhirter C. Prevalence of hypogonadism in males at least 45 years: the HIM Study. Int J Clin Pract. 2006;60(7):762-769.

Nimptsch K, Platz EA, Willett WC, Giovannucci E (2012) Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol (Oxf) 2012;77:106-112.

Pope HG, Cohane GH, Kanayama G, et al. Testosterone gel supplementation for men with refractory depression: a randomized, placebo controlled trial. Am J Psychiatry. 2003;160:105–11.

Postigo S, Lima SM, Yamada SS, et al. Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women. Rev Bras Ginecol Obstet. 2016;38:140-146

Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition 1996;12:344-348.

Raben A., Kiens B, Ritchter EA, Rasmussen LB, Svenstrup B, Micic S, Bennett P. Serum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed diet. Med. Sci. Sports Exercise. 1992;24:1290–1297

Roaiah MF, El Khayat YI Gamal El Din SF, Abd El Salam MA. Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM). J Sex Marital Ther. 2016;42(4):297-301

Rogerson S, Riches CJ, Jennings C, et al. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Strength Cond Res. 2007;21(2):348-53

Samani NB, Jokar A, Soveid M, et al. Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes. Iran J Med Sci. 2016;41(3):S5

Shamloul R. Natural aphrodisiacs. J Sex Med. 2010;7(1 Pt 1):39–49

Shin S, Jeon JH, Park D, Jang MJ. Choi JH. trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo. Arch Pham Res. 2008;31(1):83-87 Shin YS, You JH,

Sowers MF, Beebe JL, McConnell D, et al. Testosterone Concentrations in Women Aged 25–50 Years: Associations with Lifestyle, Body Composition, and Ovarian Status. Am J Epidemiol. 2001;153:256-264

Sternbach H. Age-associated testosterone decline in men: clinical issues for psychiatry. Am J Psychiatry. 1998;155:1310-1318

Swaroop A, Jaipuriar AS, Gupta SK, et al. Efficacy of a Novel Fenugreek Seed Extract (Trigonella foenum-graecum) in Polycystic Ovary Sundrome (PCOS). Int J Med Sci. 2015;12(10)825-831

Thomson CA, Chow SHH, Doe D, et al. Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial. J Cancer Epidem Biomar Preven. 2017;26(3) DOI: 10.1158/1055-9965.EPI-17-0027

Traish AM. Testosterone and weight loss: the evidence. Curr Opin Endocrinol Diabetes Obes. 2014;21:313-322

Tuncer MA, Yaymaci B, Sati L, Cayli S, Acar G, Altug T, Demir R. Influence of Tribulus terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochem. 2009;111:488–500. [PubMed: 19269683]

Van den Berghe G. The neuroendocrine response to stress is a dynamic process. Best Pract Res Clin Endocrinol Metab. 2001;15: 405-19.

Volek JS, Kraemer WJ, Bush JA, Incledon T, Boetes M. Testosterone and cortisol in relationship to dietary nutrients and resistance exercise. J Appl Physiol. 1997;82:49-54

Wang Z, Zhang D, Hui S, Zhang Y, Hu S. Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats. J Trandit Chin Med. 2013;33(2):228-232

Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnitera supplementation on muscle strength and recovery: a randomized controlled trial. J of Int Soc of Sports Nutr. 2015;12:43:1-11

Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf) 2010;73:243-248.

Low Thyroid Or Hypothyroidism: What You Need to Know

Article found here: Low Thyroid Or Hypothyroidism: What You Need to Know.

An JH, Kim YJ, Kim KJ. L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial. Endo J. 2016;63(10);885-895.

Alegre J, Roses JM, Javierre C, Ruiz-Baques A, Segundo MJ, et al. (2010) [Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndrome]. Rev Clin Esp. 2010;210:284-288.

Anthony W Norman, Gerlad Litwack. Hormones. Academic Press, Inc. 1987. Orlando, FL. Bandini LG, Schoeller DA, Dietz WH. Metabolic differences in response to a high-fat vs. a high-carbohydrate diet. Obes Res. 1994;2(4):348-54.

Bucheli P, Gao Q, Redgwell R, Vigal K, Wang J, Zhang W. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Chapter 14: Biomolecular and Clinical Aspects of Chinese Wolfberry. CRC Press/Taylor & Francis 2011.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160:526–534.

Collins AB, Pawlak R. Prevalence of vitamin B-12 deficiency among patients with thyroid dysfunction. Asia Pac J Clin Nutr. 2016;25(2):221-226.

Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379:1142-54.

Dai YL, Luk TH, Yiu KH, Wang M, Yip PM, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. 2011;216:395-401.

De Andrade PBM, Neff LA, Strosova MK, et al. Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding. Front Physiol. 2015. 

Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial. BMC Comp Alt Med. 2016;16:471

General Information/Press Room. American Thyroid Association. Retrieved April 15, 2017.

Kurmann AA, Serra M, Hawkins F, et al. Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell Stem Cell. 2015;17(5):527-42

Lee HJ, Hahn SM, Jin SL, et al. Subclinical Hypothyroidism in Childhood Cancer Survivors. Yonsei Med J. 2016;57(4):915-922

Mach J, Midgley AW, Dank S, Grant RS, Bentley DJ. The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). Nutrients. 2010;2:319-329.

McAninch EA, Bianco AC. The History and Future of Treatment of Hypothyroidism. Ann Intern Med. 2016;164(1):50-56

Meier C, Staub JJ, Roth CB, Guglielmetti M, Kunz M, Miserez AR, Drewe J, Huber P, Herzog R, Müller B. TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: A double blind, placebocontrolled trial (Basel Thyroid Study). J Clin Endocrinol Metab. 2001;86:4860–4866.

Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU. The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: Randomized, crossover trial. J Clin Endocrinol Metab.2007;92:1715–1723

Rosenfeldt F, Marasco S, Lyon W, Wowk M, Sheeran F, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005;129:25-32.

Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, et al. Psychological well-being in patients on ‘adequate’ doses of l-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf).2002;57:577-585.

Shine B, McKnight RF, Leaver L, Geddes JR. Long-term effects of lithium on renal, thyroid, and parathyroid function: a retrospective analysis of laboratory data. Lancet. 2015;386(9992):461-468

Singla R, Gupta Y, Khemani M, Aggarwai S. Thyroid disorders and polycystic ovary syndrome: An emerging relationship. Indian J Endocrinol Metab. 2015;19(1):25-29

Sosci F, Fava GA, Sonino N. Mood and anxiety disorders as early manifestations of medical illness: a systematic review. Psychother Psychosom. 2015;84(1):22-9

Tunio MA, Al Asiri M, Bayoumi Y, et al. Is thyroid gland an organ at risk in breast cancer patients treated with locoregional radiotherapy? Results of a pilot study. J Cancer Res Ther. 2015;11(4)684-9

Vidart J, Wajner SM, Schaan BD, Maia AL. Effect of N-acetylcysteine on serum thyroid hormone levels in nonthyroidal illness syndrome. Crit Care. 2013;17(Suppl 3):P37 doi: 10.1186/cc12653

Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, et al. Cognitive functioning and wellbeing in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol. 2005;153:747-753. 

Magnesium: What You Need to Know

Article found here: Magnesium: What You Need to Know.

Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients 2017;9(5):429

Derom ML, Sayón-Orea C, Martínez-Ortega JM, Martínez-González MA. Magnesium and depression: a systematic review. Nutr Neurosci 2013;16(5):191-206

Dmitrašinovi? G, Peši? V, Stani? D, et al. ACTH, Cortisol, and IL-6 Levels in Athletes Following Magnesium Supplementation. J Med Biochm 2016;35(4):375-384

Eby GA, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses 2010;74(4):649-660

Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370

Grober U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199-226.

Guerrero-Romero F, Rodriguez-Moran M. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev 2006;22:471-476.

King DE, Mainous AG, Geesey ME, Woolson RF. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005;24(3):166-171.

Laires MJ, Monteiro C. Exercise, magnesium and immune function. Mag Res 2008;21(2):92-96

Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4)971-990.

Natural News. The best and worst forms of magnesium to take as a supplement.

Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Mag Res 2006;19(3):180-189

Rayssiguier Y, Gueux E, Nowacki W, et al. High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation. Magnes Res 2006;19:237-43.

Rock E, Astier C, Lab C, et al. Dietary Magnesium deficiency in rats enhances free radical production in skeletal muscle. J Nutr 1995;125:1205-1210.

Schuchardt JP, Hahn A. Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update. Curr Nutr Food Sci 2017;13(4):260-278

Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuoron. 2010;65(2):165-177

Song Y, Manson JE, Buring JE, Liu S. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Diabetes Care 2004;27(1):59-65

Song Y, Sesso HD, Manson JE, et al. Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study. Am J Cardiol. 2006;98(12)1616-1621

Spencer H, Norris C, Williams D. Inhibitory effects of zinc on magnesium balance and magnesium absorption in man. J Am Coll Nutr 1994;13:479-84

Wang J, Liu Y, Zhou LJ, et al. Magnesium L-threonate Prevents and Restores Memory Deficits Associated with Neuropathic Pain by Inhibition of TNF-?. Pain Physician 2013;16:E563-E575

Wei Li, Jia Yu, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014;7(65)

One Reason (Of Many) to Avoid a Vegan Diet

Article found here: One Reason (Of Many) to Avoid a Vegan Diet

da Costa KA, Badea M, Fischer LM, Zeisel SH. Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr. 2004;80(1):163-70.

da Costa KA, Gaffney CE, Fischer LM, Zeisel SH. Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load. Am J Clin Nutr. 2005;81(2):440-4.

da Costa KA, Niculescu MD, Craciunescu CN, et al. Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am J Clin Nutr. 2006;84(1):88-94.

Derbyshire E. Could we be overlooking a potential choline crisis in the United Kingdom? BMJ Nutrition, Prevention & Health. 2019;bmjnph-2019-000037.

Fischer LM, daCosta KA, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007;85(5):1275-85.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B012, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy of Sciences; 1998. pp. 390–422.

Holmes-McNary MQ, Cheng WL, Mar MH, et al. Choline and choline esters in human and rat milk and in infant formulas. Am J Clin Nutr. 1996;64(4):572-6.

Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288(16):2015-22.

Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res. 2008;49(6):1187-94.

Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med. 2002;346(7):476-83.

Shaw GM, Carmichael SL, Yang W, et al. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004;160(2):102-9.

Steegers-Theunissen RP, Boers GH, Trijbels FJ, et al. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism. 1994;43(12):1475-80.

van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004;350(20):2033-41.

Wu LL, Wu JT. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta. 2002;322(1-2):21-8.

Xu X, Gammon MD, Zeisel SH, et al. Choline metabolism and risk of breast cancer in a population-based study. FASEB J. 2008;22(6):2045-52.

Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr. 2006;26():229-50.

Zeisel SH, de Costa KA. Choline: An Essential Nutrient for Public Health. Nutr Rev. 2009;67(11):615-623.

Zeisel SH, Niculescu MD. Perinatal choline influences brain structure and function. Nutr Rev. 2006;64(4):197-203.

Peppermint Essential Oil: Health and Fitness Benefits

Article found here: Peppermint Essential Oil: Health and Fitness Benefits.

Alammar N, Wang L, Saberi B, et al. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. BMC Complementary and Alternative Medicine. 2019;19:21.

Chumpitazi BP, Kearns GL, Shulman RJ. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders. Ailment Pharmacy Ther. 2018;47:738-752.

Dimidi E, Rossi M, Whelan K. Irritable bowel syndrome and diet: where are we in 2018? Curr Opin Clin Nutr Metab Care. 2017;20(6):456-463.

Ghasemi-Pirbaluti M, Motaghi E, Bozorgi H. The effect of menthol on acute experimental colitis in rats. Eur J Pharmacol. 2017;805:101-107.

Göbel H, Schmidt G, Dworschak M, et al. Essential oils and headache mechanisms. Pytomed. 1995;2(2):93-102.
Jao CN, Tan M, Matthews AP, et al. Menthol Cigarettes, Tobacco Dependence, and Smoking Persistence: The Need to Examine

Enhanced Cognitive Functioning as a Neuropsychological Mechanisms. Nicotine & Tobacco Res. 2018;1-7.

Juergens UR, Stober M, Vetter H. The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases. Eur J Med Res. 1998;3:539-545.

Khalaf MHG, Chowdhary S, Elmunzer BJ, et al. Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study. Dig Dis Sci. 2019.

Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014;48(6):505-512.

Goel N, Lao NP. Sleep changes vary by odor perception in young adults. Bio Psych. 2006;71:341-349.

Grundmann O, Yoon SL. Complementary and alternative medicines in irritable bowel syndrome: an integrative view. World J Gastroenterol. 2014;20(2):346-362.

Gastroinestinal symptom improvement from fiber, STW 5, peppermint oil, and probiotics use––Results from an online survey. Compl Ther Med. 2018;41;225-230.

Linnaeuc C. Species plantarum, Stockholm: Laurentius Salvius, 1753.

Meamarbashi A. Instant effects of peppermint essential oil on the physiological parameters and exercise performance. Avic J Phytomed. 2013;4(1):72-78.

Oh JY, Park MA, Kim YC. Peppermint Oil Promotes Hair Growth without Toxic Signs. Toxicol Res. 2014;30(4):297-304.
Meamarbashi A, Rajabi A. The effects of peppermint on exercise performance. JISSN. 2013;10:15.

Raudenbush B, Corley N, Eppich W. Enhancing athletic performance through the administration of peppermint odor. 2001. J Sport Exer Psych. 2001;23:156-160.

Raudenbush B, Meyer B, Eppich W. Effects of odor administration on objective and subjective measures of athletic performance. Int Sport J. 2002;6:1-15.

Rees WDW, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. BMJ. 1979;2(6194):835-836.
Sellaro R, vanDijk WW, Paccani CR, et al. A question of scent: lavender aroma promotes interpersonal trust. Front Psy. 2015;5(1486):1-5.

Sun Z, Wang H, Wang J, et al. Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China. PLoS ONE. 2014;9(12):3114767.

Toda M, Morimoto K. Evaluation of Effects of Lavender and Peppermint Aromatherapy Using Sensitive Salivary Endocrinological Stress Markers. Stress and Health. 2011;27:430-435.

Sleep: Why You Need It. How To Get More Of It

Article found here: Sleep: Why You Need It. How To Get More Of It.

Ali B, Al-Wabel NA, Shams S, et al. Essential oils used in aromatherapy: A systemic review. Asian Pac J Trop Biomed. 2015;5(8):601-611

American College of Cardiology. Daylight saving impacts timing of heart attacks. ScienceDaily. March 29 2014. Web

Askenasy JJ, Goldstein R. Does a subtropical climate imply a seasonal rhythm in REM sleep? Sleep. 1995; 10:895–900. [PubMed: 8746398]

Bonnet MH, Berry RB, Arand DL. Metabolism during normal, fragmented, and recovery sleep. J Appl Physiol. 1991; 71:1112–1118. [PubMed: 1757306]

Bradley BF, Starkey NJ, Brown SL, et al. Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze. J Ethnopharmacol. 2007;111:517-525

Buchbauer G, Jirovetz L, Jager W, et al. Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation. 1991;46:1067–1072

Buchbauer G, Jirovetz L, Jager W, et al. Fragrance compounds and essential oils with sedative effects upon inhalation. J Pharm Sci. 1993;82:660–664

Cell Press. Jet lag can cause obesity by disrupting the daily rhythms of gut microbes. ScienceDaily. October 16 2014. WebChaput JP, Després JP, Bouchard C, Tremblay A. Longer sleep duration associates with lower adiposity gain in adult short sleepers. Int J of Obes (2012) 36, 752–756

Chokroverty S. Overview of sleep & sleep disorders. Indian J Med Res. 2010;131:126-140

Chrousos GA, Kattah JC, Beck RW, Cleary PA. Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial. JAMA. 1993;269:2110-2112

Chrousos GA, Vgontzas AN, Kritikou I. HPA Axis and Sleep. HPA Axis and Sleep. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext. Internet. South Dartmouth (MA):, Inc. Updated 2016 Jan 18. []

de Almeida RN, Motta SC, de Brito Faturi C, et al. An- xiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats Pharmacol Biochem Behav. 2004;77:361–364

Dijk DJ. Slow-wave sleep, diabetes, and the sympathetic nervous system. PNAS. 2008;105(4):1107-1108

EurekaAlert! Sleep loss lowers testosterone in healthy young men. University of Chicago Medical Center. May 31 2011. Web.

Faturi CB, Leite JR, Alves PB, et al. Anxiolytic-like effect of sweet orange aroma in Wistar rats. Prog Neuropsycho- pharmacol Biol Psychiatry. 2010;34:605–609

Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2008;7:11 doi:10.1186/1475-2891-7-11

Kalmbach, et al. The impact of sleep on female sexual response and behavior: a pilot study. J Sex Med. 2015. doi: 10.1111/jsm.12858

Kaneita Y, Ohida T, Uchiyama M. The relationship between depression and sleep disturbances: a Japanese nationwide general population survey. J Clin Psychiatry. 2006;67(2):196-203

Lillehei AS, Halcon LL. A Systematic Review of the Effect of Inhaled Essential Oils on Sleep. J Alt Comp Med. 2014;20(6):441-451

Pizza G, Requena M, Galli G, de Jong L. Chronic sleep deprivation and seasonality: Implications for the obesity epidemic. J Endocrinol Invest. 2011;34(10):793-800

Gangwisch JE, Malaspina D. Babies LA, et al. Short Sleep Duration as a Risk Factor For Hypercholesterolemia: Analyses of the National Longitudinal Study of Adolescent Health. Sleep. 2010;33(7):956-961

Gonnissen HKJ, Hursel R, Rutters F, et al. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. Brit J Nut. 2012; doi:10.1017/S0007114512001894

Guillemain J, Rousseau A, Delaveau P. Neurodepressive effects of the essential oil of Lavandula angustifolia Mill. Ann Pharm Fr. 1989;47:337–343

Guzman-Marin R, Suntsova N, Bashir T, et al. Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat. Sleep. 2008; 31:167–175. [PubMed: 18274263]

Heath G, Roach GD, Dorrian J, et al. The effect of sleep restriction on snacking behaviour during a week of simulated shiftwork. Acid Anal Prev. 2012;45(Suppl):62-67

Komori T, Matsumoto T, Motomura E, et al. The sleep-enhancing effect of valerian inhalation and sleep shortening effect of lemon inhalation. Chem Senses. 2006;31:731–737

Knutson KL, Van Cauter E. Associations between sleep loss and increased risk of obesity and diabetes. Ann N Y Acad Sci. 2008;1129:287–304. [PubMed: 18591489]

Lis-Balchin M, Hart S. Studies on the mode of action of the essential oil of lavender (Lavandula angustifolia P. Miller). Phytother Res. 1999;13:540–542

Mallick BN, Singh A. REM sleep loss increases brain excitability: Role of noradrenalin and its mechanism of action. Sleep Med Rev. 2011

Maneschijn L, van Kruysbergen RGPM, de Jong FH, et al. Shift Work at Young Age I s Associated With Elevated Long-Term Cortisol Levels and Body Mass Index. J Clin Endorin Metab. 2011;96(11):E1862-1865

Motomura Y, Katsunuma R, Yoshimura M, Mishima K. Two Day’s Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity. Sleep. 2017;40(10)

Reynolds AC, Dorrian J, Liu PY, et al. Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men. PLoS ONE. 2012;7(7):e41218

Rohrs T, Roth T. Sleep, Sleepiness, and Alcohol Use. NIAAA. Nov 10 2013. Web

Saiyudthong S, Marsden CA. Acute effects of bergamot oil on anxiety-related behaviour and corticosterone level in rats. Phytother Res. 2011;25:858–862

Sano A, Sei H, Seno H, et al. Influence of cedar essence on spontaneous activity and sleep of rats and human daytime nap. Psychiatry Clin Neurosci. 1998;52:133–135

Spiegel K, Leproult R, L’hermite-Bale?riaux M. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004;89:5762–5771. [PubMed: 15531540]

Taheri S, Lin L, Austin D, et al. Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index. PLoS ONE. 2004;1(3):210-217

Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. JISSN. 2013;10:37

Tan D-X, Manchester LC, Terron MP, Flores LJ, Reiter RJ. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res. 2007;42(1)28-42

Telliez F, Chardon K, Leke A, et al. Thermal acclimation of neonates to prolonged cool exposure as regards sleep stages. J Sleep Res. 2004; 13:337–343. [PubMed: 15560768]

Tengattini S, Reiter RJ, Tan DX, et al. Cardiovascular disease: protective effects of melatonin. J Pineal Res. 2008;44(1)16-25

University of California – Irvine. Metabolic Output Profoundly Influenced by Circadian Rhythms. Medical News Today. MediLexicon, Intl., 21 Mar. 2012. Web.

Van Cauter E, Kerkhofs M, Caufriez A. A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrin Metab. 1992;74:1441– 1450. [PubMed: 1592892]

The 4 Best Muscle-Building Supplements

Article found here: The 4 Best Muscle-Building Supplements.

Baguet A, Koppo K, Pottier A, Derave W. Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high- intensity cycling exercise. Eur J Appl Physiol. 2010;108(3):495–503. doi:10.1007/s00421-009-1225-0.

Bellinger PM. Beta-Alanine Supplementation for Athletic Performance: An Update. J Str Cond Res. 2013;28(6):1751-1770.

Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T: Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab. 2008;18:389-398.

Clarkson PM, Hubal MJ: Exercise-induced muscle damage in humans. Am J Phys Med Rehabil. 2002;81:S52–S69.

Cooper R, Naclerio F, Allgrove J, Jimenez A. Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sport Nutr. 2012;9:33

de Salles PV, Roschel H, de Jesus F, Sale C, Harris RC, Solis MY, et al. The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance. Appl Physiol Nutr Metab. 2013;38(5):525–32. doi:10.1139/apnm-2012-0286.

Deminice R, Rosa FT, Franco GS, et al. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. J Acad Nutr Diet. 2013;29(9):1127-1132

Furst T, Williams B, Massaro A, et al. Beta-alanine supplementation improved workload capacity and cognitive function of middle-age individuals. FASEB J. 2016;30(1)Supplement:692-622.

Gallagher PM, Carrithers JA, Godard MP, et al: Beta-hydroxy-beta-methylbutyrate ingestion, part I: effects on strength and fat free mass. Med Sci Sports Exerc. 2000;32:2109–2115.

Gardner ML, Illingworth KM, Kelleher J, Wood D. Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. J Physiol. 1991;439(1):411–22. doi:10.1113/jphysiol.1991.sp018673.

Hobson RM, Harris RC, Martin D, Smith P, Macklin B, Gualano B, et al. Effect of Beta-Alanine With and Without Sodium Bicarbonate on 2,000-m Rowing Performance. Int J Sport Nutr Exerc Metab. 2013;23(5):480–7.

Hoffman JR, Landau G, Stout JR, et al. beta-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers. Amino Acids. 2015;47(3):627–36. doi:10.1007/s00726-014-1896-7.

Hoffman JR, Landau G, Stout JR, et al. beta-alanine supplementation improves tactical performance but not cognitive function in combat soldiers. J Int Soc Sports Nutr. 2014;11(1):15. doi:10.1186/1550-2783-11-15.

Hoffman J, Ratamess NA, Ross R, et al. Beta-alanine and the hormonal response to exercise. Int J Sports Med. 2008;29(12):952–8. doi:10.1055/s-2008-1038678.

Hunga W, Liub T-H, Chenc C-Y, Chang C-K: Effect of [beta]-hydroxy-[beta]- methylbutyrate Supplementation During Energy Restriction in Female Judo Athletes. J Exerc Sci Fitness 2010;8:50–53.

Jowko E, Ostaszewski P, Jank M, et al: Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition. 2001;17:558–566.

Knitter AE, Panton L, Rathmacher JA, et al: Effects of beta- hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol. 2000;89:1340–1344.

Kraemer WJ, Hatfield DL, Volek JS, et al: Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc 2009;41:1111–1121.

Lyoo K, Yoon S, Kim TS, et al. A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder. Am J Psych. 2012. doi: 10.1176/appi.ajp.2012.12010009.

McCormack W, Stout J, Emerson N, et al. Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults: a randomized, placebo-controlled study. Exp Gerontol. 2013;48(9):933-939.

Mirza KA, Pereira SL, Voss AC, et al. Comparison of the anticatabolic effects of leucine and Ca-?-hydroxy-?-methylbutyrate in experimental models of cancer cachexia. Nutrition. 2014;30(7-8):807-813

Nissen S, Sharp R, Ray M, et al: Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol. 1996;81:2095–2104.

Rawson ES, Venezia AC: Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids. 2011,40:1349-1362. 10.1007/s00726-011-0855-9.

Sale C, Saunders B, Hudson S, et al. Effect of beta-alanine plus sodium bicarbonate on high-intensity cycling capacity. Med Sci Sports Exerc. 2011;43(10):1972–8. doi:10.1249/ MSS.0b013e3182188501.

Sale C, Saunders B, Harris RC. Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance. Amino Acids. 2010;39(2):321–33. doi:10.1007/s00726-009-0443-4.

Stout JR, Smith-Ryan AE, Fukuda DH, et al. Effect of calcium ?-hydroxy-?-methylbutyrate (CaHMB) with and without resistance training in men and women 65+ yrs: A randomized, double-blind pilot trial. Exper Gerontol. 2013;48:1303-1310

Tobias G, Benatti FB, de Salles PV, et al. Additive effects of beta-alanine and sodium bicarbonate on upper- body intermittent performance. Amino Acids. 2013;45(2):309–17. doi:10.1007/s00726-013-1495-z.

Trexler ET, Smith-Ryan AE, Stout JR, et al. International society of sports nutrition position stand: Beta-Alanine. J Int Soc Sport Nutr. 2015;12:30 doi: 10.1186/s12970-015-0090-y.

Vukovich M, Dreifort G: Effect of ?-Hydroxy ?-Methylbutyrate on the Onset of Blood Lactate Accumulation and O2peak in Endurance-Trained Cyclists. J Strength Cond Res. 2001;15:491–497.

Wilkinson DJ, Hossain T, Hill DS. Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism. J Physiol. 2013:2911–2923

Wilson GJ, Wilson JM, Manninen AH: Effects of beta-hydroxy-beta- methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. Nutr Metab (Lond). 2008;5:1.

Wilson JM, Fittichen PJ, Campbell B. et al. International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sport Nutr. 2013;10:6.

Wilson JM, Lowery RP, Joy JM, et al. The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study. Our J App Physiol. 2014;114(6):1217-27.

The Best Adaptogens For Health And Fitness

Article found here: The Best Adaptogens For Health And Fitness.

Adimoelja A, Adaikan PG. Protodioscin from herbal plant Tribulus terrestris L. improves the male sexual functions, probably via DHEA. Int J Impotence Res. 1997;9:1-15.

Aggarwal BB. Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals. Annu Rev Nutr. 2010;30:173-199.

Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: a randomized double-blind placebo-controlled study. J Pharma Sci. 2014;22:40.

Amin A, Lofty M, Shafiullah M, Adeghate E. The Protective Effect of Tribulus terrestris in Diabetes. Ann NY Acad Sci. 2006;1084:391-401.

Ammon HPT, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7.

Belcaro G, Cesarone MR, Dugall M, Pellegrinai L, Ledda A, at al. Product-Evaluation Registry of Meriva®, a Curcumin-Phophatidylcholine Complex, For the Complementary Management of Osteoarthritis. Panminerva Medica. 2010;52(2).

Bhatia N, Jaggi AS, Singh N, Anand P, Dhawan R. Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis. J Nat Med. 2011;65(3–4):532–43.

Bleakney TL. Deconstructing an Adaptogen: Eleutherococcus senticosus. Hol Nurs Pract. 2008;22(4).

Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecifc resistance. Ann Rev Pharmacol Toxicol. 1969;9(1):419–30.

Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004;10:1015-1018.

Chu S, Qu W, Pang X, et al. Effect of saponin from Tribulus terrestris on hyperlipidemia. Zhong Yaho Cai. 2003;26:341-344.

Chuengsamarn S, Rattanamongkolgul S, Luechapudiportn R, Phisalaphong C, Siwanon J. Curcumin Extract for Prevention of Type 2 Diabetes. Diabetes Care. 2012;35:2121-2127.

De Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni S. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen. J Pain Res. 2013;6:201-205.

Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, et al. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomized, placebo-controlled trial. JISSN. 2014;11:31.

Edwards D, Heufelder A, Zimmerman A. Therapeutic Effects and Safety of Rhodiola rosea Extract WS® 1375 in Subjects with Life‐stress Symptoms – Results of an Open‐label Study. Phytother Res. 2012;26(8):1220-1225.

Facchinetti F, Neri I, Tarabusi M. Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial. Stress Health. 2002;18:11-17.

Gale Group. Monograph. Eletherococcus senticosus. Altern Med Rev. 2006;11(2):151-155.

Gama CRB, Lasmar R, Gustavo G, et al. Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction. Clin Med Insights. 2014;7:45-50.

Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med. 2006;12(1):50-54.

Jurenka J. Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma longa: A Review of Preclinical and Clinical Research. Alt Med Rev. 2009;14(2):141-153.

Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.

Khanum F, Bawa AS, Singh B. Rhodioloa rosea: A Versatile Adaptogen. Comp Rev Food Sci Food Saf. 2005;4(3):55-62.

Kulkarni SK, Bhutan MK, Bishnoi M. Antidepressant activity of curcumin involvement of serotonin and dopamine system. Psychopharmacology (Berl.). 2008;201:435-442.

Kulkarni SK, Dhir A, Akula KK. Potentials of Curcumin as an Antidepressant. The Scientific World Journal. 2009;9:1233-1241.

Gauthman K, Adaikan PG, Prasad RNV. Aphrodsiac properties of Tribulus terrestris extract (protodioscin) in normal and castrated rats. Life Sci. 2001;71:1385-1396.

Gauthman K, Adaikan PG, Prasad RNV, et al. Changes in hormonal parameters secondary to intravenous administration of Tribulus terrestris extract in primates. Int J Impot Res. 2000;12(Suppl 2):6.

Johnston B. Israel I Brekman 1921-1994. HerbalGram. 1995;34:67.

Kostova I, Dinchev D. Saponins in Tribulus terrestris – chemistry and bioactivity. Phytochem Rev. 2005;4:111-137.

Li M, Qu W, Wang Y, et al. Hypglycemic effect of saponin from Tribulus terrestris. Zhong Yao Cai. 2002;25:420-422.

Liao L, He Y, Meng H, et al. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018;13:57.

Alam N, Hossain M, Khalil M, et al. Recent advanced in elucidating the biological properties of Withania somnifera and its potential role in health benefits. Phytochem Rev. 2011;11(1).

Oliver F, Dugan K, McAdams M, et al. The effects of ingesting a tribulus containing proprietary supplement with combined resistance training on strength, body composition, and hormonal changes in males. J Int Soc Sport Nutr. 2010;7(Suppl 1).

Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phyochemicals. Phytochem Med Food. 2017:49-64.

Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action. Phytomed. 1999;6:327-332.

Pratte MA, Nanavati KB, Young V, Morley CP. An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera). J Altern Complement Med. 2014;20(12):901-908.

Pokrywaka A, Obminński Z, Malczewska-Lenczowska J, et al. Insights into Supplements with Tribulus Terrestris used by Athletes. J Hum Kin. 2014;41:99-105.

Ratheesh G, Tian L, Venugopal JR, et al. Role of medicinal plants in neurodegenerative disease. Biomanuf Rev. 2017;2:2.

Rogerson S, Riches CJ, Jennings C, at el. Tribulus Terrestris Supplementation on Muscle Strength and Body Composition During Preseason Training In Elite Rugby League Players. J Str Cond Res. 2007;21(2):348-353.

Ross SM. Rhodiola rose: A Proprietary Root Extract of Rhodiola rosea is found to be Effective in the Treatment of Stress-Related Fatigue. Holist Nurs Pract. 2014;28(2):149-154.

Ross SM. Rhodiola rose: A Standardized Extract of Rhodiola Rosea Is Shown To Be Effective In the Treatment of Mild to Moderate Depression. Holistic Nurs Pract. 2014;28(3):217-221.

Samani NB, Jokar A, Soveid M, et al. Efficacy of Tribulus Terrestris Extract on the Serum Glucoseand Lipids of Women with Diabetes Mellitus. Iran J Med Sci. 2016;41(3).

Salgadp RM, Marques-Silva MH, Goncalves E, et al. Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertil men. Andrologia. 2017;49(5).

Sanago S, Oskouei BS, Abdollahi NG, et al. Effect of Tribulus terrestris L. on sperm parameters in men with idiopathic infertility: A systematic review. Compl Ther Med. 2019;42:95-103.

Srinivasan M. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci. 1972;26:269-270.

Stuempfle KJ. The Effects of an Acute Dose of Rhodiola rosea. J Str Cond Res. 2013;27(3):839-847.

Sufka KJ, Roach JT, Chambliss WG, et al. Anxiolytic properties of botanical extracts in the chick social separation-stress procedure. Psychopharmacol. 2001;153(2):219-214.

Szolomicki S, Samochowiec L, Wójcicki J, Droździk M. The Influence of Active Components of Eletherococcus senticosus on Cellular Defense and Physical Fitness in Man. Phytother Res. 2000;14:30-35. Talbott S, Talbott J, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sport Nutr. 2013;10(1):37

Tommova M, Gyulemtova R, Zarkova S, et al. Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. First Intern Conf Chem Biotechnol. Bio. Active Nat Prod, Proceedings, Varna. 1981;Sept 3: 289-291.

Wiegant FAC, Surinova S, Ytsma E, et al. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontol. 2009;10:27-42.

Winslow LC, Kroll DJ. Herbs as medicines. Arch Intern Med. 1998;158(20):2192–9.

Winston D, Maimes S. Adaptogens: herbs for strength, stamina, and stress relief. Rochester: Inner Traditions/Bear & Co; 2007:48–53.

The Ultimate Guide To Keto

Article found here: The Ultimate Guide To Keto.

Ahmad MK, Mahdi AA, Sukla KK, et al. Withania somnifera improves semen quality by regulating reproductive hormone levels and antioxidative stress in seminal plasma of infertile males. Fertility and Sterility. 2010;94(3):989-996.

Ali Z, Levine B, Ripple M, Fowler DR. Diabetic Acidosis: A Silent Death. Am J Forensic Med Pathol. 2012;33:189-193.

Anderwald CH, Tura A, Gessl A. Body-Mass-Index Determines Fasting and Post-Glucose-Load Growth Hormone Concentrations. PLoS One. 2014;9(12):e115184.

Ari C, Kovács Z Juhasz G, et al. Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats. 2016;6:9: doi: 10.3389/fnmol.2016.00137.

Baranano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol. 2008;10:410–419.

Bielohuby M, Sawitzky M, Stoehr BJ, et al. Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats. Endocrinology. 2011;152(5)1948-60.

Bolster DR, Jefferson LS, Kimball SR. Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signaling. Proc Nutr Soc. 2004;4(2)351-356.

Bonuccelli G, Tsirigos A, Whitaker-Menezes D, et al. Ketones and lactate “fuel” tumor growth and metastasis. Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. 2010;9(17):3506-3514.

Brehm BJ, Seeley RJ, Daniels SR, D’Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88:1617–1623.

Brinkworth GD, Buckley JD, Noakes M, et al: Long-term effects of a very low-carbohy- drate diet and a low-fat diet on mood and cognitive function. Arch Intern Med. 2009;169:1873–1880.

Cahill Jr GF. Fuel metabolism in starvation. Annu Rev Nutr. 2006;26:1–22.

Caraballo R, Vaccarezza M, Cersósimo R, Rios V, Soraru A, et al. Long-term follow-up of the ketogenic diet for refractory epilepsy: multicenter Argentinean experience in 216 pediatric patients. Seizure. 2011;20:640–645.

Caso J, Masko EM, Li JA, et al. The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. Prostate 2013;73(5)449-454.

Chung HY, Park YK. Rationale, Feasibility and Acceptability of Ketogenic Diet for Cancer Treatment. J Cancer Prev. 2017;22(3):127-134.

Cordain L. Implications for the role of diet in acne. Semin Cutan Med Surg. 2005;24:84–91.

Cox PJ, Clarke K. Acute nutritional ketosis: implications for exercise performance and metabolism. Extreme Physiol Med. 2014;3:17 doi: 10.1186/2046-7648-3-17.

den Bêsten G, van Eunen K, Groen AK, et al. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54:2325-2340.

Duarte AI, Moreira PI, Oliverira CR. Insulin in Central Nervous System: More than Just a Peripheral Hormone. J Aging Res. 2012. doi:10.1155/2012/384017

Ehala-Aleksejev K, Punjab M. The effect of metabolic syndrome on male reproductive health: A cross-sectional study in a group of fertile men and male partners of infertile couples. PLoS. 2018;13(3):e0194395.

Feinman RD, Fine EJ. Nonequilibrium thermodynamics and energy efficiency in weight loss diets. Theor Biol Med Model. 2007;4:27.

Fernstrom JD: Tryptophan, serotonin and carbohydrate appetite: will the real carbohydrate craver please stand up! J Nutr 1998;118:1417–1419.

Fernstrom HM, Fernstrom JD: Brain tryptophan concentrations and serotonin synthesis remain responsive to food consumption after the ingestion of sequential meals. Am J Clin Nutr. 1995;61:312–319.

Fine EJ, Feinman RD. Thermodynamics of weight loss diets. Nutr Metab (Lond). 2004;1:15.

Gardner CD, Trepanowski JF, Del Gobbo LC, et al. Effect of Low-Fat vs Low Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial. JAMA. 2018;319(7):667-679.

Chen B, Huang Y, Zheng D, et al. Dietary Fatty Acids Alter Lipid Profiles and Induce Myocardial Dysfunction without Causing Metabolic Disorders in Mice. Nutrients. 2018;10:106 doi: 10.3390/nu10010106.

Frise CJ, Mackillop L. Starvation ketoacidosis. J Intens Care Soc. 2016;17(4):356.

Gaberšček S, Zaletel K, Schwetz V, et al. Thyroid and polycystic ovary syndrome. 2015;172:R9-R21.

Gupta L, Khandelwal D, Kaira S, et al. Ketogenic diet in endocrine disorders: Current perspectives. J Postgrad Med. 2017;63(4):242-251.

Hallböök T, Sunggoan J, Maudsley S, et al. The effects of the ketogenic diet on behavior and cognition. Epilepsy Res. 2012;100(3):304-309.

Halyburton AK, Brinkworth GD, Wilson CJ, et al: Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance. Am J Clin Nutr. 2007;86:580–587.

Hong AM, Turner Z, Hamdy RF, Kossoff EH. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsa 2010;51(8):1403-1407.

Frigolet ME, Barragán VER, González. Low-Carbohydrate Diets: A Matter of Love or Hate. Ann Nutr Metab. 2011;58:320-334.

Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res. 2014;55(11):2211-2228.

Harvey C, Schofield GM, Williden M. The use of nutritional supplements to induce ketosis and reduce symptoms associated with keto-induction: a narrative review. Jeer J. 2018;6: e4488  doi:  10.7717/peerj.4488.

Jeong HW, HSU KC, Lee JW, et al. Berberine suppresses pro inflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol Metab. 2009;296(4):E955-964.

Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Am J Clin Nutr. 2008;87:44–55.

Keith RE, O’Keeffe KA, Blessing DL, Wil- son GD: Alterations in dietary carbohy- drate, protein, and fat intake and mood state in trained female cyclists. Med Sci Sports Exerc. 1991;23:212–216.

Kesl SL, Poff AM, Ward NP, et al. Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats. Nutr Metab. 2016;13:9 doi: 10.1186/s12986-016-0069-y.

Khodadadi S, Sobhani N, Mirshekar S, et al. Tumor Cells Growth and Survival Time with the Ketogenic Diet in Animal Models: A Systematic Review. Int J Prev Med. 2017;8:35 doi: 10.4103/2008-7802.207035.

Kovács Z, D’Agostino D, Ari C. Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats. Front Behav Neurosci. 2018;12:29 doi: 10.3389/fnbeh.2018.00029.

Kwiterovich P, Vining EPG, Pyzik P. Effect of a High-Fat Ketogenic Diet on Plasma Levels of Lipids, Lipoproteins, and Apolipoproteins in Children. JAMA. 2003;290(7):912-920.

Lecerf JM, de Lorgeril M. Dietary cholesterol: from physiology to cardiovascular risk. Brit J Nut. 2011;106:6-14.

Leathwood PD: Tryptophan availability and serotonin synthesis. Proc Nutr Soc. 1987;46:143–156.

Manning AH. Very-low-carbohydrate diets and preservation of muscle mass. Nutr Metab (Long). 2006;3:9 doi: 10.1186/1743-7075-3-9.

Martinez CC, Pyzik PL, Kossoff EH. Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors. Epilepsia. 2007;48:187–190.

Masino SA, Ruskin DN. Ketogenic Diets and Pain. J Child Neurol. 2013;28(28):993-1001.

Mavropoulos JC, Yancy WS, Hepburn J, Westman EC. The effects of a lowcarbohydrate, ketogenic diet on the polycystic ovary syndrome: a pilot study. Nutr Metab (Lond). 2005;2:35.

McDaniel SS, Rensing NR, This LL, et al. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia 2011;52:e7-11.

McSwiney FT, Wardop B, Hyde PN, et al. Keto-adaptation enhances exercise performance and body composition responses in endurance athletes. Metabolism. 2018;81:25-34.

Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7:500-506.

Open J, Enonchong E, Kothari S. Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. Nutrition J. 2009;8:38 doi: 10.1186/1475-2891-8-38.

Pack AM. Ketogenic Diet: It Has a Role in Our Armamentarium of Treatment of Refractory Seizures. Epilepsy Curr. 2017;17(5):278-280 PMC5716494.

Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. 2013;67:789-796.

Patel A, Pyzik PL, Turner Z, Rubenstein JE, Kossoff EH. Longterm outcomes of children treated with the ketogenic diet in the past. Epilepsia. 2010;51:1277–1282.

Philippou A, Maridaki M, Halapas A. The Role of the Insulin-like Growth Factor 1 (IGF-1) in Skeletal Muscle Physiology. in vivo. 2007;21:45-54.

Ryan KK, Packard AEB, Larson KR, et al. Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21. 2018;159(1):400-413.

Santos HO. Ketogenic diet and testosterone increase: Is the increased cholesterol intake responsible? To what extend and under what circumstances can there be benefits? Hormones. 2017;16(3)266-270.

Shai I, Schwarzfuchs D, Henkin Y, et al. Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. N Engl J Med. 2008;359:229–241.

Smith D, Kelly D, Daly A, et al. Alcoholic Ketoacidosis Presenting as Diabetic Ketoacidosis. Ir J Med Sc. 1999;168(3):186-188.

Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012;3:59.

Stubbs BJ, Cox PJ, Evans RD, et al. On the Metabolism of Exogenous Ketones in Humans. Front Physiol. 2017;8:848 doi: 10.3389/fphys.2015.00848.

Thio LL. Hypothalamic Hormones and Metabolism. Epilepsy Res. 2012;100(3):245-251.

Trummer C, Pilz S, Schweiz V, et al. Vitamin D, PCOS and androgens in men: a systematic review. Endocr Connect. 2018;7(3):R95-R113.

Veldhorst M, Smeets A, Soenen S, Hochstenbach-Waelen A, Hursel R, Diepvens K et al. Protein-induced satiety: effects and mechanisms of different proteins. Physiol Behav. 2008;94:300–307.

Veldhorst MA, Westerterp-Plantenga MS, Westerterp KR. Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet. Am J Clin Nutr. 2009;90:519–526.

Volek JS, Phinney SD, Forsythe CE, et al. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids. 2009;44:297–309.

Westerterp-Plantenga MS, Nieuwenhuizen A, Tome D, Soenen S, Westerterp KR. Dietary protein, weight loss, and weight maintenance. Annu Rev Nutr. 2009;29:21–41.

Wolfsdorf J, Craig ME, Daneman D, et al. Diabetic ketoacidosis. Pediatric Diabetes. 2007;8:28-43.

Wroble KA, Trott MN, Schweitzer GG, et al. Low-carbohydrate, ketogenic diet impairs anaerobic exercise performance in exercise-trained women and men: a randomized-sequence crossover trial. J Sports Med Phys Fitness. 2018; doi: 10.23736/S0022-4707.18.08318-4.

Xu JH, Liu XZ, Pan W, Zou DJ. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017;15(5):2765-2787.

Yin J, Xing H, Ye, J. Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism. 2008;57(5):712-717.

Zhang X, Zhao Y, Zhang M, et al. Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin in High-Fat Diet-Fed Rats. PLoS One. 2012;7(8): e42529 doi:  10.1371/journal.pone.0042529.

Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7)2559-65.

Torn Bicep Tendons: How To Improve Recovery After Surgery

Article found here: Torn Bicep Tendons: How To Improve Recovery After Surgery

Andrews PJD, Avenell A, Noble D, et al. Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients. Trials. 2007;8:25.

Beks RB, Claessen FM, Oh LS, et al. Factors associated with adverse events after distal biceps tendon repair or reconstruction. J Shoulder Elbow Surg. 2016;25:1229-1234.

Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017;9:290

Christianson AG. Preliminary Overview: Clinical Relevance of Whole Body Cryotherapy.

Dobbie RP, Avulsion of lower biceps brachii tendon: analysis of fifty-one previously unreported cases. Am J Surg. 1941;51:662-683.

Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, et al. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomized, placebo-controlled trial. JISSN. 2014;11:31.

Hinchey JW, Aronowitz JG, Sanchez-Sotelo J, et al. Re-rupture rates of primarily repaired distal biceps tendon injuries. J Shoulder Elbow Surg. 2014;23:850-854.

Howard M. Current management of distal biceps tears. Curr Ortho Practice. 2018;29(2):135-139.

Hubbard TJ, Denegar CR. Does Cryotherapy Improve Outcomes With Soft Tissue Injury? J Athletic Training. 2004;39(3):278-279.

Mohammed BM, Fisher BJ, Kraskauskas D, et al. Vitamin C promotes would healing through novel pleiotropic mechanisms. Int Wound J. 2016;13(4):572-584.

Morrey BF, Askew LJ, An KN, et al. Rupture of the distal tendon of the biceps brachii. A biomechanical study. J Bone Joint Surg Am. 1985;67:418-421.

Nesterenko S, Domire ZJ, Morrey BF, et al. Elbo strength and endurance in patients with a ruptured distal biceps tendon. J Shoulder Elbo Surg. 2010;19:184-189.

Schmidt CC, Brown BT, Sawardeker PJ, et al. Factors affecting supination strength after a distal biceps rupture. J Shoulder Elbo Surg. 2014;23:68-75.

Schoemann MB, Bechtold CD, Agarwal S, et al. Glutamine and Wound Healing. Nutrition and Wound Healing. 2007. Taylor & Francis Group. Boca Raton, FL

Thaloor D, Miller KJ, Gephart J, et al. Systemic administration of the NF-kappa B inhibitor curcumin stimulates muscle regeneration after traumatic injury. Am J Physiol Cell Physiol. 1999;277:320-329.

VIGOR: 5 Simple Habits for Better Men’s Health

Article found here: VIGOR: 5 Simple Habits for Better Men’s Health.

Bouwens M, van de Rest O, Dellschaft N, et al. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009;90(2):415-24

Dabbs JM, Mohammed S. Male and female salivary testosterone concentrations before and after sexual activity. Physiol Behav. 1992;52(1):195-197

Daniells S. Low vitamin D linked to metabolic syndrome in seniors. Nutraingredients. July 2, 2010

Doheny K. Low Vitamin D Linked to Poor Diabetes Control. WebMD. July 21, 2010 (

Gröber, U. Magnesium. In Micronutrients: Metabolic Tuning-Prevention-Therapy, 1st ed.; Gröber, U., Ed.; MedPharm Scientific Publishers: Stuttgart, Germany, 2009; pp. 159–166.

Gröber W, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7:8199-8226

Gurzell EA, Teague H, Harris M, et al. DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. J of Leuk Bio. 2012;93(4):463 DOI: 10.1189/jlb.0812394

Hyman M. Vitamin D: Why You Are Probably NOT Getting Enough and How That Makes You Sick. The Huffington Post. May 22, 2010

Laino C. Low Vitamin D Levels Linked to Asthma. WebMD. March 3, 2010

Mavrommati K, Sentissi O. Delirium as a result of vitamin B12 deficiency in a vegetarian female patient. Eur J Clin Nutr. 2013;67:996-997 doi:10.1038/ejcn.2013.128

Medical News Today. Vitamin D Expert Says More Than Half The World’s Population Gets Insufficient Vitamin D. Medical News Today online article. July 19, 2010. (

Shahar D, Schwarzfuch D, Fraser D, et al. Dairy calcium intake, serum vitamin D, and successful weight loss. Am J Clin Nutr. September 1, 2010, published ahead of print

Smith GI, Atherton P, Reeds DN, et al. Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperaminoacidemia-hyperinsulinemia in healthy young and middle aged men and women. Clin Sci (Lond). 2011;121(6):267-278

Swanson D, Block R, Mousa SA. Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life. Adv Nutr. 2012;3:1-7 doi: 10.3945/ an.111.000893

Vitamin D Deficiency Symptoms And Benefits Of Supplementation

Article found here: Vitamin D Deficiency Symptoms And Benefits Of Supplementation

Cannell JJ, Vieth R, Umhau JC, et al. Epidemic influence and vitamin D. Epidemiol Infect. 2006;134:1129-1140

Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. Brit Med Bulletin. 2018;126:57-77.

Doheny K. Low Vitamin D Linked to Poor Diabetes Control. /WebMD/. July 21, 2010 ( )

Grant W. In defense of the sun: An estimate of changes in mortality rates in the United States if mean serum 25-hydroxyvitamin D levels were raised to 45 ng/mL by solar ultraviolet-B irradiance. Dermato Endocrinology. 2009;1(4):207-214.

Heaney RP. What Is Vitamin D Insufficiency? And Does It Matter? Calcif Tissue Int. 2013;92:177-183.

Hyman M. Vitamin D: Why You Are Probably NOT Getting Enough and How That Makes You Sick. The Huffington Post. May 22, 2010.

Juzeniene A, Grigalavicius M, Juraleviciute M, Grant WB. Phytotherapy and vitamin D. Clinics in Dermatology. 2016;34:548-555.

Kamycheva E, Joakimsen RM, Jorde R. Intakes of calcium and vitamin d predict body mass index in the population of Northern Norway. J Nutr. 2003;133:201-6.

Laino C. Low Vitamin D Levels Linked to Asthma. WebMD. March 3, 2010.

McGreevey S. More Pregnant Women Not Getting Enough Vitamin D. Medical News Today. May 12, 2010.

Medical News Today. Low Levels Of Vitamin D Linked To Muscle Fat, Decreased Strength In Young People. Medical News Today online article

Medical News Today. Vitamin D Expert Says More Than Half The World’s Population Gets Insufficient Vitamin D. Medical News Today online article. July 19, 2010.

Oh J, Weing S, Felton SK, et al. 1,25(OH) vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus. Circulation. 2009;120(8):687-698.

Raloff J. Vitamin D is a flu fighter. ScienceNews. March 16, 2010.

Shahar D, Schwarzfuch D, Fraser D, et al. Dairy calcium intake, serum vitamin D, and successful weight loss. /Am J Clin Nutr/. September 1, 2010, published ahead of print.

Silva MC, Furlanetto TW. Intestinal absorption of vitamin D: a systematic review. Nutrition Rev. 2018;76(1)60-76

Steenhuysen J. More than three quarters of U.S. flu shots ineffective–report. Reuters. January 2015. Retrieved Sept 6 2018.

Tirbassi G, Salvio G, Altieri B, et al. Adrenal disorders: Is there any role for vitamin D? Rev Endocrine Metab Disord. 2017;18:355-362

Urashima M, Takaaki S, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in school children. Am J Clin Nutr. 2010;91:1255-1260.

Vitamin D Council. For health professionals: Position statement on supplementation, blood levels and sun exposure. Retrieved Sept 9 2018.

von Hurst P, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial. Brit Jour Nutr. 2010;103:549-555.

WebMd. Treating Vitamin D Deficiency Significantly Reduces Heart Disease Risk. WebMD online article, source: Jess Gomez, Intermountain Medical Center.

Wellcome Trust. Vitamin D Found to Influence Over 200 Genes, Highlighting Links to Disease. ScienceDaily 24 August 2010.

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Article found here: Why Corporate Wellness Programs Don’t Work

Centers for Disease Control and Prevention. Adult Obesity Causes & Consequences. Overweight & Obesity. Retrieved April 20 2019.

IBIS World. Corporate Wellness Services Industry in the US. April 2018 and February 2016.

Kaiser Family Foundation. 2018 Employer Health Benefits Survey. Published October 3, 2018. Accessed April 18 2019.

Matke S, Schnyer C, Van Busum KR. A Review of the U.S. Workplace Wellness Market. Rand Health. 2012.

Mazur B, Mazur-Malek M. Towards Corporate Wellness: Health Culture and Wellness Programs. J Intercultural Manage. 2017;9)3):45-61.

Pollitz K, Rae M. Workplace wellness programs: characteristics and requirements. Kaiser Family Foundation. Published May 19, 2016. Accessed April 18 2019.

Robroek SJW, van de Varthorst S, Hilhorst M, Burdon A. Moral issues in workplace health promotion. Int Arch Occup Environ Health. 2012;85(3):327-331.

Song Z, Baicker K. Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes. JAMA. 2019;321(15):1491-1501.

United Healthcare. News Release. Nearly 60 Percent of Employees with Access to a Company Wellness Program Say the Initiative Has Made a Positive Impact on Their Health. Published June 7 2017. Retrieved April 20 2019.–wellness-program.html